STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
sucDsucCoAalpha: succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)    
Predicted Functional Partners:
sucC
sucCoAbeta: succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
AHY45296.1
COG:COG1053: Succinate dehydrogenase/fumarate reductase flavoprotein subunit [Energy production and conversion]; Pfam:PF00890:FAD binding domain; Pfam:PF00890:FAD binding domain; SUPERFAMILY:SSF51905:No Description.
 0.986
AHY45297.1
TIGRFAM:TIGR00384:Succinate dehydrogenase/fumarate reductase iron-sulphur protein; COG:COG0479: Succinate dehydrogenase/fumarate reductase Fe-S protein subunit [Energy production and conversion]; Pfam:PF13085:Succinate dehydogenase/fumarate reductase N-terminal; ProSitePatterns:PS00197:2Fe-2S ferredoxin, iron-sulphur binding site; ProSiteProfiles:PS51085:2Fe-2S ferredoxin-type domain; SUPERFAMILY:SSF54292:2Fe-2S ferredoxin-type domain.
 
 0.985
AHY45701.1
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.956
AHY45700.1
TIGRFAM:TIGR00239:2-oxoglutarate dehydrogenase, E1 component; COG:COG0567: 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component and related enzymes [Energy production and conversion]; Pfam:PF02779:Transketolase-like, pyrimidine-binding domain; PIRSF:PIRSF000157:2-oxoglutarate dehydrogenase, E1 component; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description;KEGG: 00020; KEGG: 00310; KEGG: 00380; MetaCyc: PWY-5084; 2oxo_dh_E1.
 
 0.939
AHY47343.1
TIGRFAM:TIGR00640:Methylmalonyl-CoA mutase, C-terminal; COG:COG2185: Methylmalonyl-CoA mutase C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Pfam:PF02310:Cobalamin (vitamin B12)-binding domain; ProSiteProfiles:PS51332:Cobalamin (vitamin B12)-binding domain; SUPERFAMILY:SSF52242:Cobalamin (vitamin B12)-binding domain;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; acid_CoA_mut_C.
    
 0.929
AHY45710.1
TIGRFAM:TIGR00641:Methylmalonyl-CoA mutase, alpha chain, catalytic; COG:COG1884: Methylmalonyl-CoA mutase N-terminal domain/subunit [Lipid metabolism]; Pfam:PF01642:Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; SUPERFAMILY:SSF51703:Cobalamin (vitamin B12)-dependent enzyme, catalytic;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; acid_CoA_mut_N.
    
 0.912
AHY46541.1
TIGRFAM:TIGR00641:Methylmalonyl-CoA mutase, alpha chain, catalytic; COG:COG1884: Methylmalonyl-CoA mutase N-terminal domain/subunit [Lipid metabolism]; Pfam:PF01642:Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; SUPERFAMILY:SSF51703:Cobalamin (vitamin B12)-dependent enzyme, catalytic;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; acid_CoA_mut_N.
    
 0.912
AHY46975.1
COG:COG1804: Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Pfam:PF02515:CoA-transferase family III; Pfam:PF02515:CoA-transferase family III; SUPERFAMILY:SSF89796:CoA-transferase family III domain; Belongs to the CoA-transferase III family.
   
  0.909
AHY46988.1
COG:COG2030: Acyl dehydratase [Lipid metabolism]; Pfam:PF01575:MaoC-like domain; Pfam:PF01575:MaoC-like domain; SUPERFAMILY:SSF54637:No Description.
  
 
 0.907
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (22%) [HD]
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