STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46554.1COG:COG0473: Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00180:Isopropylmalate dehydrogenase-like domain; Pfam:PF00180:Isopropylmalate dehydrogenase-like domain; ProSitePatterns:PS00470:Isocitrate/isopropylmalate dehydrogenase, conserved site; SUPERFAMILY:SSF53659:No Description. (334 aa)    
Predicted Functional Partners:
AHY47511.1
COG:COG1048: Aconitase A [Energy production and conversion]; Pfam:PF00330:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Pfam:PF00330:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; PRINTS:PR00415:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SUPERFAMILY:SSF53732:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha.
 
 0.947
AHY45700.1
TIGRFAM:TIGR00239:2-oxoglutarate dehydrogenase, E1 component; COG:COG0567: 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component and related enzymes [Energy production and conversion]; Pfam:PF02779:Transketolase-like, pyrimidine-binding domain; PIRSF:PIRSF000157:2-oxoglutarate dehydrogenase, E1 component; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description;KEGG: 00020; KEGG: 00310; KEGG: 00380; MetaCyc: PWY-5084; 2oxo_dh_E1.
   
 0.917
AHY47141.1
COG:COG0473: Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00180:Isopropylmalate dehydrogenase-like domain; Pfam:PF00180:Isopropylmalate dehydrogenase-like domain; SUPERFAMILY:SSF53659:No Description.
  
  
 
0.917
AHY47837.1
COG:COG0069: Glutamate synthase domain 2 [Amino acid transport and metabolism]; Pfam:PF01645:Glutamate synthase, central-C; ProSiteProfiles:PS51278:Glutamine amidotransferase type 2 domain; SUPERFAMILY:SSF51395:No Description;UniPathway: UPA00045.
  
 
 0.913
leuC
leuC: 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.876
AHY46968.1
COG:COG0436: Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
 
 
 0.841
argH
TIGRFAM:TIGR00838:Argininosuccinate lyase; COG:COG0165: Argininosuccinate lyase [Amino acid transport and metabolism]; Pfam:PF00206:Fumarate lyase, N-terminal; Hamap:MF_00006:Argininosuccinate lyase; PRINTS:PR00145:Delta crystallin; ProSitePatterns:PS00163:Fumarate lyase, conserved site; SUPERFAMILY:SSF48557:L-Aspartase-like;KEGG: 00250; KEGG: 00330; MetaCyc: PWY-4983; MetaCyc: PWY-5; UniPathway: UPA00068.
  
 
 0.829
leuD
leuD: 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
 0.824
AHY45918.1
COG:COG1012: NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Pfam:PF00171:Aldehyde dehydrogenase domain; Pfam:PF00171:Aldehyde dehydrogenase domain; SUPERFAMILY:SSF53720:Aldehyde/histidinol dehydrogenase.
  
 0.820
AHY46946.1
COG:COG1012: NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Pfam:PF00171:Aldehyde dehydrogenase domain; Pfam:PF00171:Aldehyde dehydrogenase domain; ProSitePatterns:PS00070:Aldehyde dehydrogenase, conserved site; SUPERFAMILY:SSF53720:Aldehyde/histidinol dehydrogenase.
  
 0.820
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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