STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDTIGRFAM:TIGR00110:Dihydroxy-acid dehydratase; COG:COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Pfam:PF00920:Dihydroxy-acid/6-phosphogluconate dehydratase; Hamap:MF_00012:Dihydroxy-acid dehydratase; ProSitePatterns:PS00886:Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site; SUPERFAMILY:SSF143975:No Description;KEGG: 00290; KEGG: 00770; MetaCyc: PWY-5103; UniPathway: UPA00047; UniPathway: UPA00049; Belongs to the IlvD/Edd family. (561 aa)    
Predicted Functional Partners:
ilvC
ilvC: ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.993
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.978
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.976
AHY45495.1
TIGRFAM:TIGR00977:2-isopropylmalate synthase/homocitrate synthase-related; COG:COG0119: Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Pfam:PF00682:Pyruvate carboxyltransferase; ProSitePatterns:PS00815:Alpha-isopropylmalate/homocitrate synthase, conserved site; ProSiteProfiles:PS50991:Pyruvate carboxyltransferase; SMART:SM00917:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SUPERFAMILY:SSF51569:No Description;KEGG: 00966; LeuA_rel; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.957
AHY45504.1
TIGRFAM:TIGR00118:Acetolactate synthase, large subunit, biosynthetic; COG:COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; ProSitePatterns:PS00187:TPP-binding enzyme, conserved site; SUPERFAMILY:SSF52518:No Description;KEGG: 00290; KEGG: 00650; KEGG: 00660; KEGG: 00770; MetaCyc: PWY-5103; MetaCyc: PWY-5939; UniPathway: UPA00047; UniPathwa [...]
  
 0.933
AHY46003.1
Dehydratase family; COG:COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Pfam:PF00920:Dihydroxy-acid/6-phosphogluconate dehydratase; SUPERFAMILY:SSF52016:Aconitase/3-isopropylmalate dehydratase, swivel;MetaCyc: PWY-5103; UniPathway: UPA00047; UniPathway: UPA00049; Belongs to the IlvD/Edd family.
  
  
 
0.929
AHY45729.1
COG:COG0334: Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00208:Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Pfam:PF00208:Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; PIRSF:PIRSF000188:Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal; PRINTS:PR00082:Glutamate/phenylalanine/leucine/valine dehydrogenase; ProSitePatterns:PS00074:Glutamate/phenylalanine/leucine/va line dehydrogenase; SMART:SM00839:Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; SUPERFAMILY:SSF5 [...]
   
 0.917
panB
panB: 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     
 0.913
leuC
leuC: 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.852
AHY46126.1
COG:COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; ProSitePatterns:PS00187:TPP-binding enzyme, conserved site; SUPERFAMILY:SSF52518:No Description.
  
 0.843
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.