STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobB-2COG:COG0846: NAD-dependent protein deacetylases SIR2 family [Transcription]; Pfam:PF02146:Sirtuin family; Hamap:MF_01121:Sirtuin, classIII; Pfam:PF02146:Sirtuin family; ProSiteProfiles:PS50305:Sirtuin family, catalytic core domain; SUPERFAMILY:SSF52467:No Description; Belongs to the sirtuin family. Class III subfamily. (247 aa)    
Predicted Functional Partners:
nadE
nadE: NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
   
 0.950
nadD
TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.932
nadK
Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.920
AHY47526.1
COG:COG0813: Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Pfam:PF01048:Nucleoside phosphorylase domain; Pfam:PF01048:Nucleoside phosphorylase domain; ProSitePatterns:PS01232:Nucleoside phosphorylase, conserved site; SUPERFAMILY:SSF53167:No Description.
    
 0.919
AHY45583.1
Protein of unknown function (DUF3814); COG:COG3288: NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Pfam:PF12769:NAD(P) transhydrogenase, alpha subunit, C-terminal.
    
 0.908
AHY45584.1
COG:COG3288: NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Pfam:PF05222:Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal; Pfam:PF05222:Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal; PIRSF:PIRSF000203:NAD(P) transhydrogenase, alpha subunit; SMART:SM01003:Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal; SUPERFAMILY:SSF52283:No Description.
    
 0.908
AHY47352.1
COG:COG2816: NTP pyrophosphohydrolases containing a Zn-finger probably nucleic-acid-binding [DNA replication recombination and repair]; Pfam:PF00293:NUDIX hydrolase domain; Pfam:PF00293:NUDIX hydrolase domain; ProSitePatterns:PS00893:NUDIX hydrolase, conserved site; ProSiteProfiles:PS51462:NUDIX hydrolase domain; SUPERFAMILY:SSF55811:NUDIX hydrolase domain-like.
    
 0.908
AHY45582.1
NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.902
AHY45729.1
COG:COG0334: Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00208:Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Pfam:PF00208:Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; PIRSF:PIRSF000188:Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal; PRINTS:PR00082:Glutamate/phenylalanine/leucine/valine dehydrogenase; ProSitePatterns:PS00074:Glutamate/phenylalanine/leucine/va line dehydrogenase; SMART:SM00839:Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; SUPERFAMILY:SSF5 [...]
   
 0.827
AHY46617.1
COG:COG0491: Zn-dependent hydrolases including glyoxylases [General function prediction only]; Pfam:PF00753:Beta-lactamase-like; Pfam:PF00753:Beta-lactamase-like; SMART:SM00849:Beta-lactamase-like; SUPERFAMILY:SSF56281:No Description.
  
   0.790
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (28%) [HD]
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