STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribBAribA: GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (409 aa)    
Predicted Functional Partners:
AHY46653.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 0.999
AHY46654.1
ribE: riboflavin synthase, alpha subunit; TIGRFAM:TIGR00187:Lumazine-binding protein; COG:COG0307: Riboflavin synthase alpha chain [Coenzyme metabolism]; Pfam:PF00677:Lumazine-binding domain; PIRSF:PIRSF000498:Lumazine-binding protein; ProSiteProfiles:PS51177:Lumazine-binding domain; SUPERFAMILY:SSF63380:Riboflavin synthase-like beta-barrel;KEGG: 00740; MetaCyc: PWY-6167; UniPathway: UPA00275.
 
 0.999
ribH
Lumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
AHY47405.1
TIGRFAM:TIGR00227:Riboflavin-specific deaminase, C-terminal; COG:COG1985: Pyrimidine reductase riboflavin biosynthesis [Coenzyme metabolism]; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; SUPERFAMILY:SSF53597:Dihydrofolate reductase-like domain;KEGG: 00740; UniPathway: UPA00275; ribD_Cterm.
 0.999
AHY46719.1
COG:COG1985: Pyrimidine reductase riboflavin biosynthesis [Coenzyme metabolism]; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; SUPERFAMILY:SSF53597:Dihydrofolate reductase-like domain.
 
 
 0.956
folE
COG:COG0302: GTP cyclohydrolase I [Coenzyme metabolism]; Pfam:PF01227:GTP cyclohydrolase I/Nitrile oxidoreductase; Hamap:MF_00223:GTP cyclohydrolase I; Pfam:PF01227:GTP cyclohydrolase I/Nitrile oxidoreductase; ProSitePatterns:PS00859:GTP cyclohydrolase I, conserved site; SUPERFAMILY:SSF55620:No Description.
  
 
 0.953
moaA
moaA: molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
 0.904
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.892
AHY46615.1
RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.851
AHY45979.1
TIGRFAM:TIGR01304:IMP dehydrogenase-related 2; COG:COG0516: IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Pfam:PF00478:IMP dehydrogenase/GMP reductase; SUPERFAMILY:SSF51412:No Description;KEGG: 00121; KEGG: 00231; KEGG: 00520; KEGG: 00592; KEGG: 00633; KEGG: 00860; KEGG: 00906; KEGG: 00950; KEGG: 00981; IMP_DH_rel_2.
  
  
 0.829
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.