STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribHLumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (172 aa)    
Predicted Functional Partners:
AHY46654.1
ribE: riboflavin synthase, alpha subunit; TIGRFAM:TIGR00187:Lumazine-binding protein; COG:COG0307: Riboflavin synthase alpha chain [Coenzyme metabolism]; Pfam:PF00677:Lumazine-binding domain; PIRSF:PIRSF000498:Lumazine-binding protein; ProSiteProfiles:PS51177:Lumazine-binding domain; SUPERFAMILY:SSF63380:Riboflavin synthase-like beta-barrel;KEGG: 00740; MetaCyc: PWY-6167; UniPathway: UPA00275.
 
 0.999
ribBA
ribA: GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 0.999
AHY46653.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
 0.995
metK
metK: methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.982
AHY47405.1
TIGRFAM:TIGR00227:Riboflavin-specific deaminase, C-terminal; COG:COG1985: Pyrimidine reductase riboflavin biosynthesis [Coenzyme metabolism]; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; SUPERFAMILY:SSF53597:Dihydrofolate reductase-like domain;KEGG: 00740; UniPathway: UPA00275; ribD_Cterm.
 
 
 0.908
AHY46719.1
COG:COG1985: Pyrimidine reductase riboflavin biosynthesis [Coenzyme metabolism]; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; SUPERFAMILY:SSF53597:Dihydrofolate reductase-like domain.
 
 
 0.875
AHY46704.1
ribF: riboflavin biosynthesis protein RibF; TIGRFAM:TIGR00083:Riboflavin kinase, bacterial; COG:COG0196: FAD synthase [Coenzyme metabolism]; Pfam:PF06574:FAD synthetase; PIRSF:PIRSF004491:Riboflavin kinase, bacterial; SMART:SM00904:Riboflavin kinase domain, bacterial/eukaryotic; SUPERFAMILY:SSF82114:Riboflavin kinase domain, bacterial/eukaryotic;KEGG: 00740; MetaCyc: PWY-5523; MetaCyc: PWY-6167; UniPathway: UPA00276; UniPathway: UPA00277; Belongs to the ribF family.
  
  
 0.845
pyrB
TIGRFAM:TIGR00670:Aspartate carbamoyltransferase; COG:COG0540: Aspartate carbamoyltransferase catalytic chain [Nucleotide transport and metabolism]; Pfam:PF02729:Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Hamap:MF_00001:Aspartate carbamoyltransferase; PRINTS:PR00101:Aspartate carbamoyltransferase; ProSitePatterns:PS00097:Aspartate/ornithine carbamoyltransferase; SUPERFAMILY:SSF53671:Aspartate/ornithine carbamoyltransferase;KEGG: 00240; KEGG: 00250; MetaCyc: PWY-5686; UniPathway: UPA00070; asp_carb_tr; Belongs to the aspartate/ornithine carbamoyltransferase superfami [...]
  
    0.806
nusB
nusB: transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.768
glmS
glmS: glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
      0.654
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.