STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fabHfabH: 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (322 aa)    
Predicted Functional Partners:
AHY46668.1
COG:COG0331: (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Pfam:PF00698:Acyl transferase; Pfam:PF00698:Acyl transferase; PIRSF:PIRSF000446:Malonyl CoA-acyl carrier protein transacylase; SMART:SM00827:Polyketide synthase, acyl transferase domain; SUPERFAMILY:SSF52151:Acyl transferase/acyl hydrolase/lysophospholipase.
 
 
 0.997
AHY46672.1
fabF: beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 0.997
AHY46323.1
COG:COG0304: 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis transport and catabolism]; Pfam:PF00109:Beta-ketoacyl synthase, N-terminal; Pfam:PF00109:Beta-ketoacyl synthase, N-terminal; SMART:SM00825:Polyketide synthase, beta-ketoacyl synthase domain; SUPERFAMILY:SSF53901:Thiolase-like; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 0.995
AHY45525.1
COG:COG0331: (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Pfam:PF00698:Acyl transferase; Pfam:PF00698:Acyl transferase; SMART:SM00827:Polyketide synthase, acyl transferase domain; SUPERFAMILY:SSF52151:Acyl transferase/acyl hydrolase/lysophospholipase.
 
 
 0.993
plsX
plsX: fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
 
  
 0.993
fabZ
fabZ: beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
 
  
 0.989
AHY47153.1
Carboxyl transferase domain; COG:COG0777: Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Pfam:PF01039:Carboxyl transferase; PRINTS:PR01070:Acetyl-CoA carboxylase carboxyl transferase, beta subunit; ProSiteProfiles:PS50989:Acetyl-coenzyme A carboxyltransferase, C-terminal; SUPERFAMILY:SSF52096:No Description;MetaCyc: PWY-5744; UniPathway: UPA00655.
 
 
 0.984
AHY46670.1
3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.981
AHY45320.1
BCCP: acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 
 0.973
AHY46205.1
Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 
 0.972
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (16%) [HD]
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