STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (357 aa)    
Predicted Functional Partners:
ispF
ispF: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
 
  
 0.988
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
 
 
 0.984
dxr
Dxr: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
   
 0.952
ispD
ispD: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
 
   
 0.887
ispE
ispE: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
   
 0.878
pgk
COG:COG0126: 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Pfam:PF00162:Phosphoglycerate kinase; Hamap:MF_00145:Phosphoglycerate kinase; Pfam:PF00162:Phosphoglycerate kinase; PIRSF:PIRSF000724:Phosphoglycerate kinase; PRINTS:PR00477:Phosphoglycerate kinase; ProSitePatterns:PS00111:Phosphoglycerate kinase, conserved site; SUPERFAMILY:SSF53748:Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
  
 
 0.689
AHY46694.1
TIGR00054: RIP metalloprotease RseP; TIGRFAM:TIGR00054:Peptidase M50, putative membrane-associated zinc metallopeptidase; COG:COG0750: Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis outer membrane]; Pfam:PF02163:Peptidase M50; ProSiteProfiles:PS50106:PDZ domain; SMART:SM00228:PDZ domain; SUPERFAMILY:SSF50156:PDZ domain.
 
     0.666
hisS
hisS: histidine--tRNA ligase; TIGRFAM:TIGR00442:Histidine-tRNA ligase; COG:COG0124: Histidyl-tRNA synthetase [Translation ribosomal structure and biogenesis]; Pfam:PF13393:Histidyl-tRNA synthetase; Hamap:MF_00127:Histidine-tRNA ligase; PIRSF:PIRSF001549:Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit; ProSiteProfiles:PS50862:Aminoacyl-tRNA synthetase, class II; SUPERFAMILY:SSF55681:No Description;KEGG: 00970; Reactome: REACT_71.
  
  
 0.589
AHY46691.1
uppS: di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
  
  
 0.588
AHY46692.1
COG:COG0575: CDP-diglyceride synthetase [Lipid metabolism]; Pfam:PF01148:Phosphatidate cytidylyltransferase; Pfam:PF01148:Phosphatidate cytidylyltransferase; ProSitePatterns:PS01315:Phosphatidate cytidylyltransferase; Belongs to the CDS family.
     
 0.580
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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