STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46719.1COG:COG1985: Pyrimidine reductase riboflavin biosynthesis [Coenzyme metabolism]; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; Pfam:PF01872:Bacterial bifunctional deaminase-reductase, C-terminal; SUPERFAMILY:SSF53597:Dihydrofolate reductase-like domain. (239 aa)    
Predicted Functional Partners:
ribBA
ribA: GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 
 0.956
AHY46654.1
ribE: riboflavin synthase, alpha subunit; TIGRFAM:TIGR00187:Lumazine-binding protein; COG:COG0307: Riboflavin synthase alpha chain [Coenzyme metabolism]; Pfam:PF00677:Lumazine-binding domain; PIRSF:PIRSF000498:Lumazine-binding protein; ProSiteProfiles:PS51177:Lumazine-binding domain; SUPERFAMILY:SSF63380:Riboflavin synthase-like beta-barrel;KEGG: 00740; MetaCyc: PWY-6167; UniPathway: UPA00275.
 
  
 0.876
ribH
Lumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.875
hflX
GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
  
    0.781
AHY46717.1
COG:COG0324: tRNA delta(2)-isopentenylpyrophosphate transferase [Translation ribosomal structure and biogenesis]; Pfam:PF01715:tRNA isopentenyltransferase; Pfam:PF01715:tRNA isopentenyltransferase; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
    0.715
AHY46716.1
TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family; TIGRFAM:TIGR00089:Methylthiotransferase; COG:COG0621: 2-methylthioadenine synthetase [Translation ribosomal structure and biogenesis]; Pfam:PF04055:Radical SAM; ProSitePatterns:PS01278:Methylthiotransferase, conserved site; ProSiteProfiles:PS50926:TRAM domain; SMART:SM00729:Elongator protein 3/MiaB/NifB; SUPERFAMILY:SSF102114:No Description;KEGG: 00231; KEGG: 00540.
     
 0.624
AHY46714.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60.
       0.594
AHY46715.1
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COG:COG3290: Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Pfam:PF02518:Histidine kinase-like ATPase, ATP-binding domain; SUPERFAMILY:SSF55874:Histidine kinase-like ATPase, ATP-binding domain.
       0.594
rny
Ribonuclease Y; Endoribonuclease that initiates mRNA decay.
       0.590
AHY46704.1
ribF: riboflavin biosynthesis protein RibF; TIGRFAM:TIGR00083:Riboflavin kinase, bacterial; COG:COG0196: FAD synthase [Coenzyme metabolism]; Pfam:PF06574:FAD synthetase; PIRSF:PIRSF004491:Riboflavin kinase, bacterial; SMART:SM00904:Riboflavin kinase domain, bacterial/eukaryotic; SUPERFAMILY:SSF82114:Riboflavin kinase domain, bacterial/eukaryotic;KEGG: 00740; MetaCyc: PWY-5523; MetaCyc: PWY-6167; UniPathway: UPA00276; UniPathway: UPA00277; Belongs to the ribF family.
  
  
 0.458
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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