STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AHY46761.1Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (368 aa)    
Predicted Functional Partners:
AHY45300.1
Flavoprotein; COG:COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Pfam:PF02441:Flavoprotein; SUPERFAMILY:SSF52507:Flavoprotein.
 
  
  0.997
coaD
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.946
coaA
Pantothenate kinase; TIGRFAM:TIGR00554:Bacterial pantothenate kinase; COG:COG1072: Panthothenate kinase [Coenzyme metabolism]; Pfam:PF00485:Phosphoribulokinase/uridine kinase; Hamap:MF_00215:Bacterial pantothenate kinase; PIRSF:PIRSF000545:Bacterial pantothenate kinase; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase;KEGG: 00770; MetaCyc: PWY-3961; UniPathway: UPA00241; panK_bact.
   
 
 0.927
panC
panC: pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
 
 0.867
AHY46968.1
COG:COG0436: Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
 
  0.863
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 0.816
AHY48030.1
COG:COG0031: Cysteine synthase [Amino acid transport and metabolism]; Pfam:PF00291:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily; Pfam:PF00291:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily; ProSitePatterns:PS00901:Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site; SUPERFAMILY:SSF53686:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily.
    
  0.807
AHY46759.1
COG:COG1198: Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication recombination and repair]; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
 
    0.780
rpoZ
rpoZ: DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
    0.732
pyrR
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
     0.730
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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