STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (450 aa)    
Predicted Functional Partners:
pyrB
TIGRFAM:TIGR00670:Aspartate carbamoyltransferase; COG:COG0540: Aspartate carbamoyltransferase catalytic chain [Nucleotide transport and metabolism]; Pfam:PF02729:Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Hamap:MF_00001:Aspartate carbamoyltransferase; PRINTS:PR00101:Aspartate carbamoyltransferase; ProSitePatterns:PS00097:Aspartate/ornithine carbamoyltransferase; SUPERFAMILY:SSF53671:Aspartate/ornithine carbamoyltransferase;KEGG: 00240; KEGG: 00250; MetaCyc: PWY-5686; UniPathway: UPA00070; asp_carb_tr; Belongs to the aspartate/ornithine carbamoyltransferase superfami [...]
 0.999
pyrD
Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.998
carB
TIGRFAM:TIGR01369:Carbamoyl-phosphate synthase, large subunit; COG:COG0458: Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Pfam:PF02786:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; Hamap:MF_01210_B:Carbamoyl-phosphate synthase, large subunit; PRINTS:PR00098:Carbamoyl-phosphate synthase large subunit, CPSase domain; ProSitePatterns:PS00866:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; ProSiteProfiles:PS50975:ATP-grasp fold; SMART:SM01096:Carbamoyl [...]
 
 0.996
carA
TIGRFAM:TIGR01368:Carbamoyl-phosphate synthase, small subunit; COG:COG0505: Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Pfam:PF00988:Carbamoyl-phosphate synthase, small subunit N-terminal domain; Hamap:MF_01209:Carbamoyl-phosphate synthase, small subunit; PRINTS:PR00099:Carbamoyl-phosphate synthase protein GATase domain signature; ProSiteProfiles:PS51273:Glutamine amidotransferase; SMART:SM01097:Carbamoyl-phosphate synthase, small subunit N-terminal domain; SUPERFAMILY:SSF52317:No Description;KEGG: 00240; KEGG: [...]
  
 0.996
AHY46766.1
COG:COG0543: 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Pfam:PF10418:Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Pfam:PF10418:Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PIRSF:PIRSF006816:Cytochrome-c3 hydrogenase, gamma subunit; ProSiteProfiles:PS51384:Ferredoxin reductase-type FAD-binding domain; SUPERFAMILY:SSF52343:No Description.
 
 
 0.995
pyrR
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
 
 0.977
AHY47584.1
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
 
  
 0.913
AHY45796.1
TIGRFAM:TIGR02127:Orotidine 5'-phosphate decarboxylase, type 2; COG:COG0284: Orotidine-5'-phosphate decarboxylase [Nucleotide transport and metabolism]; Pfam:PF00215:Orotidine 5'-phosphate decarboxylase domain; SMART:SM00934:Orotidine 5'-phosphate decarboxylase domain; SUPERFAMILY:SSF51366:Ribulose-phosphate binding barrel;KEGG: 00240; MetaCyc: PWY-5686; UniPathway: UPA00070; pyrF_sub2.
 
  
 0.815
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.810
AHY46764.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60.
   
   0.803
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (12%) [HD]
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