STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46808.1TIGRFAM:TIGR01128:DNA polymerase III, delta subunit; COG:COG1466: DNA polymerase III delta subunit [DNA replication recombination and repair]; Pfam:PF06144:DNA polymerase III, delta; SUPERFAMILY:SSF48019:DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. (307 aa)    
Predicted Functional Partners:
AHY46338.1
TIGRFAM:TIGR00594:DNA polymerase III, alpha subunit; COG:COG0587: DNA polymerase III alpha subunit [DNA replication recombination and repair]; Pfam:PF07733:Bacterial DNA polymerase III, alpha subunit; SMART:SM00481:Polymerase/histidinol phosphatase, N-terminal; SUPERFAMILY:SSF89550:Polymerase/histidinol phosphatase-like;KEGG: 00230; KEGG: 00240.
  
 0.989
AHY45285.1
Dnan: DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiat [...]
   
 0.988
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.980
AHY47023.1
COG:COG0470: ATPase involved in DNA replication [DNA replication recombination and repair]; Pfam:PF13177:DNA polymerase III, delta subunit; Pfam:PF13177:DNA polymerase III, delta subunit; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
   
 0.980
AHY45537.1
TIGRFAM:TIGR00573:DNA polymerase III, epsilon subunit; COG:COG0322: Nuclease subunit of the excinuclease complex [DNA replication recombination and repair]; Pfam:PF00929:Exonuclease, RNase T/DNA polymerase III; ProSiteProfiles:PS50151:UVR domain; SMART:SM00479:Exonuclease; SUPERFAMILY:SSF53098:Ribonuclease H-like domain;KEGG: 00230; KEGG: 00240.
    
 0.960
AHY46809.1
TIGRFAM:TIGR00360:ComEC/Rec2-related protein; COG:COG0658: Predicted membrane metal-binding protein [General function prediction only]; Pfam:PF03772:ComEC/Rec2-related protein; ComEC_N-term.
     
 0.830
AHY46810.1
Helix-hairpin-helix motif; COG:COG1555: DNA uptake protein and related DNA-binding proteins [DNA replication recombination and repair]; Pfam:PF12836:Helix-hairpin-helix motif; SMART:SM00278:Helix-hairpin-helix DNA-binding motif, class 1; SUPERFAMILY:SSF47781:RuvA domain 2-like.
       0.751
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
     
 0.630
nadD
TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
    0.558
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.516
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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