STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46827.1folC: bifunctional protein FolC; TIGRFAM:TIGR01499:Folylpolyglutamate synthetase; COG:COG0285: Folylpolyglutamate synthase [Coenzyme metabolism]; Pfam:PF02875:Mur ligase, C-terminal; SUPERFAMILY:SSF53623:Mur ligase, central;KEGG: 00790; MetaCyc: PWY-2161; UniPathway: UPA00850. (423 aa)    
Predicted Functional Partners:
AHY45561.1
DHPS: dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.997
AHY47254.1
DHPS: dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.997
valS
valS: valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
  
 0.910
AHY47253.1
folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; TIGRFAM:TIGR01498:7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; COG:COG0801: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Pfam:PF01288:7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; SUPERFAMILY:SSF55083:7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK;KEGG: 00790; MetaCyc: PWY-6147; UniPathway: UPA00077.
  
 0.776
folE
COG:COG0302: GTP cyclohydrolase I [Coenzyme metabolism]; Pfam:PF01227:GTP cyclohydrolase I/Nitrile oxidoreductase; Hamap:MF_00223:GTP cyclohydrolase I; Pfam:PF01227:GTP cyclohydrolase I/Nitrile oxidoreductase; ProSitePatterns:PS00859:GTP cyclohydrolase I, conserved site; SUPERFAMILY:SSF55620:No Description.
  
  
 0.721
AHY47406.1
folB: dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.721
guaA
GMP synthase (glutamine-hydrolyzing), C-terminal domain; Catalyzes the synthesis of GMP from XMP.
 
  
 0.719
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
 
  
 0.586
clpX
clpX: ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
     
 0.576
folD
510-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
   
 0.564
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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