STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46871.1COG:COG2131: Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Pfam:PF00383:CMP/dCMP deaminase, zinc-binding; Pfam:PF00383:CMP/dCMP deaminase, zinc-binding; PIRSF:PIRSF006019:dCMP deaminase; ProSitePatterns:PS00903:APOBEC/CMP deaminase, zinc-binding; SUPERFAMILY:SSF53927:Cytidine deaminase-like. (167 aa)    
Predicted Functional Partners:
dut
Dut: dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 0.938
tdk
COG:COG1435: Thymidine kinase [Nucleotide transport and metabolism]; Pfam:PF00265:Thymidine kinase; Hamap:MF_00124:Thymidine kinase, subgroup; Pfam:PF00265:Thymidine kinase; PIRSF:PIRSF035805:Thymidine kinase; ProSitePatterns:PS00603:Thymidine kinase, conserved site; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
 
 0.927
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.924
AHY45658.1
thyX: thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
  0.908
cmk
TIGRFAM:TIGR00017:Cytidylate kinase; COG:COG0283: Cytidylate kinase [Nucleotide transport and metabolism]; Pfam:PF02224:Cytidylate kinase domain; Hamap:MF_00238:Cytidylate kinase; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase;KEGG: 00240.
    
  0.902
surE
surE: 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
AHY46872.1
Upp: uracil phosphoribosyltransferase; TIGRFAM:TIGR01091:Uracil phosphoribosyl transferase; COG:COG0035: Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pfam:PF00156:Phosphoribosyltransferase domain; SUPERFAMILY:SSF53271:No Description;KEGG: 00240; UniPathway: UPA00574; Belongs to the UPRTase family.
  
  
 0.830
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.827
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
      0.684
hisF
hisF: imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
      0.656
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (24%) [HD]
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