STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46900.1TIGRFAM:TIGR01798:Citrate synthase, type II; COG:COG0372: Citrate synthase [Energy production and conversion]; Pfam:PF00285:Citrate synthase-like; PIRSF:PIRSF001369:Citrate synthase, bacterial-type; PRINTS:PR00143:Citrate synthase-like; ProSitePatterns:PS00480:Citrate synthase active site; SUPERFAMILY:SSF48256:Citrate synthase-like, core;KEGG: 00020; KEGG: 00630; MetaCyc: PWY-5750; UniPathway: UPA00223; cit_synth_I; Belongs to the citrate synthase family. (443 aa)    
Predicted Functional Partners:
AHY47511.1
COG:COG1048: Aconitase A [Energy production and conversion]; Pfam:PF00330:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Pfam:PF00330:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; PRINTS:PR00415:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SUPERFAMILY:SSF53732:Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha.
 
 0.995
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.987
acsA
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.963
AHY47138.1
TIGRFAM:TIGR01344:Malate synthase A; COG:COG2225: Malate synthase [Energy production and conversion]; Pfam:PF01274:Malate synthase; PIRSF:PIRSF001363:Malate synthase A; ProSitePatterns:PS00510:Malate synthase, conserved site; SUPERFAMILY:SSF51645:Malate synthase-like;KEGG: 00620; KEGG: 00630; UniPathway: UPA00703; malate_syn_A; Belongs to the malate synthase family.
   
 0.961
AHY47470.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.961
AHY45862.1
Alpha/beta hydrolase family; COG:COG0596: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Pfam:PF12697:Alpha/beta hydrolase family; PRINTS:PR00111:Alpha/beta hydrolase fold-1; ProSitePatterns:PS00189:2-oxo acid dehydrogenase, lipoyl-binding site; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF53474:No Description.
  
 0.958
sucC
sucCoAbeta: succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.953
AHY45766.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSitePatterns:PS00189:2-oxo acid dehydrogenase, lipoyl-binding site; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
  
 0.949
AHY46932.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
  
 0.949
AHY47759.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
  
 0.949
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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