STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLhemL: glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM:TIGR00713:Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; COG:COG0001: Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Pfam:PF00202:Aminotransferase class-III; Hamap:MF_00375:Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; PIRSF:PIRSF000521:No Description; ProSitePatterns:PS00600:Aminotransferase class-III; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase;KEGG: 00860; MetaCyc: PWY-5188; UniPathway: UPA00251. (442 aa)    
Predicted Functional Partners:
AHY47037.1
COG:COG0113: Delta-aminolevulinic acid dehydratase [Coenzyme metabolism]; Pfam:PF00490:Porphobilinogen synthase; Pfam:PF00490:Porphobilinogen synthase; PIRSF:PIRSF001415:Porphobilinogen synthase; PRINTS:PR00144:Porphobilinogen synthase; ProSitePatterns:PS00169:Porphobilinogen synthase; SMART:SM01004:Porphobilinogen synthase; SUPERFAMILY:SSF51569:No Description; Belongs to the ALAD family.
 
 
 0.997
hemA
hemA: glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.995
hemC
hemC: porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.975
AHY45894.1
TIGRFAM:TIGR01746:Thioester reductase domain; COG:COG3320: Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis transport and catabolism]; Pfam:PF00501:AMP-dependent synthetase/ligase; ProSitePatterns:PS00012:Phosphopantetheine attachment site; ProSiteProfiles:PS50075:Acyl carrier protein-like; SMART:SM00823:Polyketide synthase, phosphopantetheine-binding domain; SUPERFAMILY:SSF56801:No Description.
  
 
 0.972
AHY47041.1
TIGRFAM:TIGR01470:Sirohaem synthase, N-terminal; COG:COG1648: Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Pfam:PF13241:Sirohaem synthase, N-terminal; SUPERFAMILY:SSF51735:No Description;KEGG: 00860; MetaCyc: PWY-5194; MetaCyc: PWY-5196; UniPathway: UPA00148; UniPathway: UPA00148; UniPathway: UPA00262; UniPathway: UPA00262; UniPathway: UPA00262; cysG_Nterm.
   
 0.931
AHY47038.1
TIGRFAM:TIGR01469:Uroporphyrin-III C-methyltransferase; COG:COG0007: Uroporphyrinogen-III methylase [Coenzyme metabolism]; Pfam:PF02602:Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; ProSitePatterns:PS00840:Uroporphiryn-III C-methyltransferase, conserved site; SUPERFAMILY:SSF53790:Tetrapyrrole methylase;KEGG: 00860; MetaCyc: PWY-5194; MetaCyc: PWY-5196; UniPathway: UPA00148; UniPathway: UPA00148; UniPathway: UPA00262; UniPathway: UPA00262; UniPathway: UPA00262; cobA_cysG_Cterm.
 
  
 0.929
AHY47033.1
COG:COG0142: Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Pfam:PF00348:Polyprenyl synthetase; Pfam:PF00348:Polyprenyl synthetase; ProSitePatterns:PS00444:Polyprenyl synthetase; SUPERFAMILY:SSF48576:Terpenoid synthase; Belongs to the FPP/GGPP synthase family.
       0.784
menG
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
       0.773
AHY47035.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60.
       0.773
AHY46668.1
COG:COG0331: (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Pfam:PF00698:Acyl transferase; Pfam:PF00698:Acyl transferase; PIRSF:PIRSF000446:Malonyl CoA-acyl carrier protein transacylase; SMART:SM00827:Polyketide synthase, acyl transferase domain; SUPERFAMILY:SSF52151:Acyl transferase/acyl hydrolase/lysophospholipase.
    
 0.660
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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