STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hisITIGRFAM:TIGR03188:Phosphoribosyl-ATP pyrophosphohydrolase; COG:COG0139: Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Pfam:PF01502:Phosphoribosyl-AMP cyclohydrolase domain; Hamap:MF_01020:Phosphoribosyl-ATP pyrophosphohydrolase; SUPERFAMILY:SSF141734:No Description;KEGG: 00340; UniPathway: UPA00031; histidine_hisI; In the N-terminal section; belongs to the PRA-CH family. (216 aa)    
Predicted Functional Partners:
hisZ
ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 
 
 0.999
hisG
hisG: ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
 
 0.999
hisD
hisD: histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
hisB
COG:COG0131: Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism]; Pfam:PF00475:Imidazoleglycerol-phosphate dehydratase; Hamap:MF_00076:Imidazoleglycerol-phosphate dehydratase; Pfam:PF00475:Imidazoleglycerol-phosphate dehydratase; ProSitePatterns:PS00954:Imidazoleglycerol-phosphate dehydratase, conserved site; SUPERFAMILY:SSF54211:Ribosomal protein S5 domain 2-type fold.
  
 0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
 0.999
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM:TIGR00007:Phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA; COG:COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Pfam:PF00977:Histidine biosynthesis; Hamap:MF_01014:Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; SUPERFAMILY:SSF51366:Ribulose-phosphate binding barrel;KEGG: 00340; UniPathway: UPA00031.
 
 0.999
hisF
hisF: imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.999
AHY46111.1
COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
 
  
 0.997
hisC
COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Hamap:MF_01023:Histidinol-phosphate aminotransferase family; Pfam:PF00155:Aminotransferase, class I/classII; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.997
AHY47180.1
TIGRFAM:TIGR01490:HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; COG:COG0560: Phosphoserine phosphatase [Amino acid transport and metabolism]; Pfam:PF07993:Male sterility, NAD-binding; SUPERFAMILY:SSF51735:No Description.
  
  
 0.994
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (14%) [HD]
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