STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47254.1DHPS: dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa)    
Predicted Functional Partners:
AHY47253.1
folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; TIGRFAM:TIGR01498:7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; COG:COG0801: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Pfam:PF01288:7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; SUPERFAMILY:SSF55083:7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK;KEGG: 00790; MetaCyc: PWY-6147; UniPathway: UPA00077.
 
 0.999
AHY46827.1
folC: bifunctional protein FolC; TIGRFAM:TIGR01499:Folylpolyglutamate synthetase; COG:COG0285: Folylpolyglutamate synthase [Coenzyme metabolism]; Pfam:PF02875:Mur ligase, C-terminal; SUPERFAMILY:SSF53623:Mur ligase, central;KEGG: 00790; MetaCyc: PWY-2161; UniPathway: UPA00850.
 
 0.997
AHY47406.1
folB: dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 
 0.986
folE
COG:COG0302: GTP cyclohydrolase I [Coenzyme metabolism]; Pfam:PF01227:GTP cyclohydrolase I/Nitrile oxidoreductase; Hamap:MF_00223:GTP cyclohydrolase I; Pfam:PF01227:GTP cyclohydrolase I/Nitrile oxidoreductase; ProSitePatterns:PS00859:GTP cyclohydrolase I, conserved site; SUPERFAMILY:SSF55620:No Description.
  
 0.922
AHY45561.1
DHPS: dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
  
 
0.914
ftsH
ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.818
greA
greA: transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
       0.571
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
       0.517
AHY47256.1
Pfam:PF13469:Sulfotransferase family; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
    0.516
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
  
 0.514
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.