STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47257.1HGPRTase: hypoxanthine phosphoribosyltransferase; TIGRFAM:TIGR01203:Hypoxanthine phosphoribosyl transferase; COG:COG0634: Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Pfam:PF00156:Phosphoribosyltransferase domain; SUPERFAMILY:SSF53271:No Description;KEGG: 00230; KEGG: 00983; MetaCyc: PWY-6599; MetaCyc: PWY-6609; UniPathway: UPA00591; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (188 aa)    
Predicted Functional Partners:
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
  
 0.982
guaA
GMP synthase (glutamine-hydrolyzing), C-terminal domain; Catalyzes the synthesis of GMP from XMP.
  
 
 0.953
purA
purA: adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.937
apt
Apt: adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
 0.937
AHY45979.1
TIGRFAM:TIGR01304:IMP dehydrogenase-related 2; COG:COG0516: IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Pfam:PF00478:IMP dehydrogenase/GMP reductase; SUPERFAMILY:SSF51412:No Description;KEGG: 00121; KEGG: 00231; KEGG: 00520; KEGG: 00592; KEGG: 00633; KEGG: 00860; KEGG: 00906; KEGG: 00950; KEGG: 00981; IMP_DH_rel_2.
    
 0.931
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.929
adk
Adk: adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
  
 0.919
purH
purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM:TIGR00355:AICARFT/IMPCHase bienzyme; COG:COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Pfam:PF01808:AICARFT/IMPCHase bienzyme; Hamap:MF_00139:AICARFT/IMPCHase bienzyme; PIRSF:PIRSF000414:AICARFT/IMPCHase bienzyme; SMART:SM00798:AICARFT/IMPCHase bienzyme; SUPERFAMILY:SSF53927:Cytidine deaminase-like;KEGG: 00230; KEGG: 00670; MetaCyc: PWY-6123; UniPathway: UPA00074; UniPathway: UPA00074.
    
 0.915
AHY47526.1
COG:COG0813: Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Pfam:PF01048:Nucleoside phosphorylase domain; Pfam:PF01048:Nucleoside phosphorylase domain; ProSitePatterns:PS01232:Nucleoside phosphorylase, conserved site; SUPERFAMILY:SSF53167:No Description.
     
 0.909
AHY46940.1
COG:COG1001: Adenine deaminase [Nucleotide transport and metabolism]; Pfam:PF13382:Adenine deaminase C-terminal domain; Pfam:PF13382:Adenine deaminase C-terminal domain; SUPERFAMILY:SSF51338:Metal-dependent hydrolase, composite domain.
    
 0.907
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (28%) [HD]
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