STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47273.1COG:COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes [Energy production and conversion]; Pfam:PF07992:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; Pfam:PF07992:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; PRINTS:PR00411:Pyridine nucleotide disulphide reductase class-I signature; SUPERFAMILY:SSF51905:No Description. (457 aa)    
Predicted Functional Partners:
AHY47758.1
Dehydrogenase E1 component; COG:COG0022: Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit [Energy production and conversion]; Pfam:PF00676:Dehydrogenase, E1 component; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description.
 
 0.973
AHY45766.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSitePatterns:PS00189:2-oxo acid dehydrogenase, lipoyl-binding site; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
 0.884
AHY45700.1
TIGRFAM:TIGR00239:2-oxoglutarate dehydrogenase, E1 component; COG:COG0567: 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component and related enzymes [Energy production and conversion]; Pfam:PF02779:Transketolase-like, pyrimidine-binding domain; PIRSF:PIRSF000157:2-oxoglutarate dehydrogenase, E1 component; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description;KEGG: 00020; KEGG: 00310; KEGG: 00380; MetaCyc: PWY-5084; 2oxo_dh_E1.
  
 0.802
AHY46932.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
 0.788
AHY47759.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
 0.783
AHY45701.1
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.775
AHY45714.1
COG:COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes [Energy production and conversion]; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; Pfam:PF00198:2-oxoacid dehydrogenase acyltransferase, catalytic domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF52777:No Description.
 0.765
AHY45713.1
COG:COG0022: Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit [Energy production and conversion]; Pfam:PF02779:Transketolase-like, pyrimidine-binding domain; Pfam:PF02779:Transketolase-like, pyrimidine-binding domain; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description.
 0.723
AHY45862.1
Alpha/beta hydrolase family; COG:COG0596: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Pfam:PF12697:Alpha/beta hydrolase family; PRINTS:PR00111:Alpha/beta hydrolase fold-1; ProSitePatterns:PS00189:2-oxo acid dehydrogenase, lipoyl-binding site; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SUPERFAMILY:SSF53474:No Description.
  
 0.688
AHY45765.1
Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.687
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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