STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47343.1TIGRFAM:TIGR00640:Methylmalonyl-CoA mutase, C-terminal; COG:COG2185: Methylmalonyl-CoA mutase C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Pfam:PF02310:Cobalamin (vitamin B12)-binding domain; ProSiteProfiles:PS51332:Cobalamin (vitamin B12)-binding domain; SUPERFAMILY:SSF52242:Cobalamin (vitamin B12)-binding domain;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; acid_CoA_mut_C. (134 aa)    
Predicted Functional Partners:
AHY45710.1
TIGRFAM:TIGR00641:Methylmalonyl-CoA mutase, alpha chain, catalytic; COG:COG1884: Methylmalonyl-CoA mutase N-terminal domain/subunit [Lipid metabolism]; Pfam:PF01642:Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; SUPERFAMILY:SSF51703:Cobalamin (vitamin B12)-dependent enzyme, catalytic;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; acid_CoA_mut_N.
 0.999
AHY46541.1
TIGRFAM:TIGR00641:Methylmalonyl-CoA mutase, alpha chain, catalytic; COG:COG1884: Methylmalonyl-CoA mutase N-terminal domain/subunit [Lipid metabolism]; Pfam:PF01642:Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; SUPERFAMILY:SSF51703:Cobalamin (vitamin B12)-dependent enzyme, catalytic;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; acid_CoA_mut_N.
 0.999
AHY46540.1
TIGRFAM:TIGR03081:Methylmalonyl-CoA epimerase; COG:COG3185: 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Pfam:PF13669:Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; SUPERFAMILY:SSF54593:No Description;KEGG: 00280; KEGG: 00640; MetaCyc: PWY-5743; metmalonyl_epim.
  
 0.996
AHY45702.1
Lao: LAO/AO transport system ATPase; TIGRFAM:TIGR00750:ArgK protein; COG:COG1703: Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Pfam:PF03308:ArgK protein; SMART:SM00382:AAA+ ATPase domain; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
 0.987
sucD
sucCoAalpha: succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.929
sucC
sucCoAbeta: succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.925
AHY45872.1
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; COG:COG0346: Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Pfam:PF13669:Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; SUPERFAMILY:SSF54593:No Description.
    
 0.916
AHY47470.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
    
 0.837
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
    
 0.827
pckA
pckA: phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
     
 0.827
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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