STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCCOG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Hamap:MF_01023:Histidinol-phosphate aminotransferase family; Pfam:PF00155:Aminotransferase, class I/classII; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa)    
Predicted Functional Partners:
hisB
COG:COG0131: Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism]; Pfam:PF00475:Imidazoleglycerol-phosphate dehydratase; Hamap:MF_00076:Imidazoleglycerol-phosphate dehydratase; Pfam:PF00475:Imidazoleglycerol-phosphate dehydratase; ProSitePatterns:PS00954:Imidazoleglycerol-phosphate dehydratase, conserved site; SUPERFAMILY:SSF54211:Ribosomal protein S5 domain 2-type fold.
 
 0.998
hisI
TIGRFAM:TIGR03188:Phosphoribosyl-ATP pyrophosphohydrolase; COG:COG0139: Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Pfam:PF01502:Phosphoribosyl-AMP cyclohydrolase domain; Hamap:MF_01020:Phosphoribosyl-ATP pyrophosphohydrolase; SUPERFAMILY:SSF141734:No Description;KEGG: 00340; UniPathway: UPA00031; histidine_hisI; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.997
AHY47443.1
COG:COG0287: Prephenate dehydrogenase [Amino acid transport and metabolism]; Pfam:PF02153:Prephenate dehydrogenase; Pfam:PF02153:Prephenate dehydrogenase; ProSiteProfiles:PS51176:Prephenate dehydrogenase; SUPERFAMILY:SSF51735:No Description.
 
 
 0.993
hisD
hisD: histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.982
AHY46506.1
COG:COG0077: Prephenate dehydratase [Amino acid transport and metabolism]; Pfam:PF00800:Prephenate dehydratase; Pfam:PF00800:Prephenate dehydratase; PIRSF:PIRSF001500:Bifunctional P-protein, chorismate mutase/prephenate dehydratase; ProSiteProfiles:PS51168:Chorismate mutase; SMART:SM00830:Chorismate mutase; SUPERFAMILY:SSF53850:No Description.
  
 
 0.956
AHY46968.1
COG:COG0436: Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
 
 
0.928
AHY46111.1
COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
  
  
 
0.927
AHY47401.1
TIGRFAM:TIGR01856:Histidinol phosphate phosphatase, HisJ; COG:COG1387: Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Pfam:PF02811:PHP, C-terminal; SUPERFAMILY:SSF89550:Polymerase/histidinol phosphatase-like;UniPathway: UPA00031; hisJ_fam; Belongs to the PHP hydrolase family. HisK subfamily.
 
 
 0.924
AHY47456.1
COG:COG0483: Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Pfam:PF00459:Inositol monophosphatase; Pfam:PF00459:Inositol monophosphatase; PRINTS:PR00377:Inositol monophosphatase; ProSitePatterns:PS00629:Inositol monophosphatase, metal-binding site; SUPERFAMILY:SSF56655:No Description.
  
 
 0.912
AHY47867.1
Acetyltransferase (GNAT) family; COG:COG1670: Acetyltransferases including N-acetylases of ribosomal proteins [Translation ribosomal structure and biogenesis]; Pfam:PF00583:GNAT domain; ProSiteProfiles:PS51186:GNAT domain; SUPERFAMILY:SSF55729:Acyl-CoA N-acyltransferase.
    
  0.900
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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