STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
menBmenB: naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (283 aa)    
Predicted Functional Partners:
AHY47592.1
TIGRFAM:TIGR01923:O-succinylbenzoate-CoA ligase; COG:COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis transport and catabolism]; Pfam:PF00501:AMP-dependent synthetase/ligase; ProSitePatterns:PS00455:AMP-binding, conserved site; SUPERFAMILY:SSF56801:No Description;KEGG: 00130; MetaCyc: PWY-5791; MetaCyc: PWY-5837; UniPathway: UPA00079.
  
 0.994
menC
O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
  
 0.980
menH
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
   
 0.972
AHY47818.1
Hypothetical protein; TIGRFAM:TIGR00369:Phenylacetic acid degradation-related domain; COG:COG2050: Uncharacterized protein possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis transport and catabolism]; Pfam:PF03061:Thioesterase superfamily; SUPERFAMILY:SSF54637:No Description; unchar_dom_1.
 
  
 0.955
menD
menD: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
  
 0.945
menF
Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.
 
   
 0.895
menA
menA: 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.853
AHY47839.1
COG:COG1250: 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Pfam:PF02737:3-hydroxyacyl-CoA dehydrogenase, NAD binding; Pfam:PF02737:3-hydroxyacyl-CoA dehydrogenase, NAD binding; PIRSF:PIRSF000105:3-hydroxyacyl-CoA dehydrogenase; SUPERFAMILY:SSF51735:No Description.
    
 0.813
AHY47596.1
Hypothetical protein; COG:COG3791: Uncharacterized conserved protein [Function unknown]; Pfam:PF04828:Glutathione-dependent formaldehyde-activating enzyme/centromere protein V; Pfam:PF04828:Glutathione-dependent formaldehyde-activating enzyme/centromere protein V; SUPERFAMILY:SSF51316:Mss4-like.
       0.768
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
      
 0.545
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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