STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47638.1COG:COG0420: DNA repair exonuclease [DNA replication recombination and repair]; Pfam:PF12850:Calcineurin-like phosphoesterase superfamily domain; Pfam:PF12850:Calcineurin-like phosphoesterase superfamily domain; SUPERFAMILY:SSF56300:No Description. (395 aa)    
Predicted Functional Partners:
AHY47639.1
RecF/RecN/SMC N terminal domain; COG:COG0419: ATPase involved in DNA repair [DNA replication recombination and repair]; Pfam:PF02463:RecF/RecN/SMC; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
 
 0.999
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
  
 0.984
AHY46467.1
TIGRFAM:TIGR00614:DNA helicase, ATP-dependent, RecQ type; COG:COG0514: Superfamily II DNA helicase [DNA replication recombination and repair]; Pfam:PF00570:HRDC domain; ProSitePatterns:PS00690:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; ProSiteProfiles:PS51194:Helicase, C-terminal; SMART:SM00487:Helicase, superfamily 1/2, ATP-binding domain; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; recQ_fam.
  
 0.913
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.845
AHY47329.1
sulP: sulfate permease; TIGRFAM:TIGR00815:Sulphate anion transporter; COG:COG0659: Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Pfam:PF00916:Sulphate transporter; ProSitePatterns:PS01130:Sulphate anion transporter, conserved site; ProSiteProfiles:PS50801:STAS domain; SUPERFAMILY:SSF52091:STAS domain;Reactome: REACT_15518.
  
   0.806
AHY47636.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
 
   
 0.758
recX
Hypothetical protein; Modulates RecA activity; Belongs to the RecX family.
 
  
 0.626
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 0.606
AHY47637.1
COG:COG4405: Uncharacterized protein conserved in bacteria [Function unknown]; Pfam:PF04266:ASCH domain; Pfam:PF04266:ASCH domain; PIRSF:PIRSF021320:Protein of unknown function DUF984; SMART:SM01022:ASCH domain; SUPERFAMILY:SSF88697:PUA-like domain.
       0.597
AHY45304.1
Metallo-beta-lactamase superfamily; COG:COG1236: Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation ribosomal structure and biogenesis]; Pfam:PF00753:Beta-lactamase-like; SMART:SM00849:Beta-lactamase-like; SUPERFAMILY:SSF56281:No Description.
  
 0.559
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (14%) [HD]
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