STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
thiMthiM: hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (264 aa)    
Predicted Functional Partners:
thiE
thiE: thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiE-2
thiE: thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
AHY47716.1
TIGRFAM:TIGR00097:Phosphomethylpyrimidine kinase type-2; COG:COG0351: Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism]; Pfam:PF08543:Phosphomethylpyrimidine kinase type-1; SUPERFAMILY:SSF53613:No Description;KEGG: 00730; UniPathway: UPA00060; HMP-P_kinase.
  
 0.998
AHY47709.1
Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family.
 
 
 0.957
AHY45865.1
COG:COG0819: Putative transcription activator [Transcription]; Pfam:PF03070:Thiaminase-2/PQQ biosynthesis protein C; Pfam:PF03070:Thiaminase-2/PQQ biosynthesis protein C; SUPERFAMILY:SSF48613:Haem oxygenase-like, multi-helical.
 
 
 0.954
thiG
thiS: thiamine biosynthesis protein ThiS; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
  
 0.922
AHY47714.1
thiW: thiW protein; TIGRFAM:TIGR02359:ThiW; COG:COG4732: Predicted membrane protein [Function unknown]; Pfam:PF09512:ThiW; PIRSF:PIRSF024534:ThiW.
 
     0.878
AHY47717.1
COG:COG0715: ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components [Inorganic ion transport and metabolism]; Pfam:PF09084:NMT1/THI5-like; Pfam:PF09084:NMT1/THI5-like; ProSiteProfiles:PS51318:Twin-arginine translocation pathway, signal sequence; SUPERFAMILY:SSF53850:No Description.
     
 0.840
thiL
thiL: thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
     
 0.825
AHY47711.1
NUDIX domain; COG:COG1051: ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Pfam:PF00293:NUDIX hydrolase domain; PRINTS:PR00502:NUDIX hydrolase; ProSitePatterns:PS00893:NUDIX hydrolase, conserved site; ProSiteProfiles:PS51462:NUDIX hydrolase domain; SUPERFAMILY:SSF55811:NUDIX hydrolase domain-like; Belongs to the Nudix hydrolase family.
       0.773
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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