STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47788.1Cobalamin-independent synthase, Catalytic domain; COG:COG0620: Methionine synthase II (cobalamin-independent) [Amino acid transport and metabolism]; Pfam:PF01717:Methionine synthase, vitamin-B12 independent; SUPERFAMILY:SSF51726:No Description;MetaCyc: PWY-702; UniPathway: UPA00051. (381 aa)    
Predicted Functional Partners:
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
  
 0.999
AHY46012.1
metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.977
metK
metK: methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.975
AHY47060.1
COG:COG0499: S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Pfam:PF05221:Adenosylhomocysteinase; Pfam:PF05221:Adenosylhomocysteinase; PIRSF:PIRSF001109:Adenosylhomocysteinase; SMART:SM00996:Adenosylhomocysteinase; SUPERFAMILY:SSF52283:No Description.
  
 
 0.963
AHY46330.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; TIGRFAM:TIGR01326:O-acetylhomoserine/O-acetylserine sulfhydrylase; COG:COG2873: O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Pfam:PF01053:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PIRSF:PIRSF001434:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; ProSitePatterns:PS00868:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase;KEGG: 00270; MetaCyc: PWY-5344; OAH_OAS_sulfhy.
  
 
 0.938
metG
metG: methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.914
AHY46105.1
4Fe-4S dicluster domain; COG:COG4231: Indolepyruvate ferredoxin oxidoreductase alpha and beta subunits [Energy production and conversion]; Pfam:PF13187:4Fe-4S ferredoxin-type, iron-sulpur binding domain; ProSitePatterns:PS00198:4Fe-4S ferredoxin, iron-sulphur binding, conserved site; ProSiteProfiles:PS51379:4Fe-4S ferredoxin-type, iron-sulpur binding domain; SUPERFAMILY:SSF54862:No Description.
     
  0.900
AHY46332.1
COG:COG0460: Homoserine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00742:Homoserine dehydrogenase, catalytic; Pfam:PF00742:Homoserine dehydrogenase, catalytic; PIRSF:PIRSF036497:Homoserine dehydrogenase, short; SUPERFAMILY:SSF55347:No Description.
   
 
 0.878
thrB
thrB: homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
   
 
 0.861
AHY48030.1
COG:COG0031: Cysteine synthase [Amino acid transport and metabolism]; Pfam:PF00291:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily; Pfam:PF00291:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily; ProSitePatterns:PS00901:Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site; SUPERFAMILY:SSF53686:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily.
   
 
 0.854
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (14%) [HD]
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