STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47828.1UvrD-like helicase C-terminal domain; COG:COG0210: Superfamily I DNA and RNA helicases [DNA replication recombination and repair]; Pfam:PF13361:DNA helicase, UvrD-like, C-terminal; ProSiteProfiles:PS51217:DNA helicase, UvrD-like, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the helicase family. UvrD subfamily. (1055 aa)    
Predicted Functional Partners:
AHY45997.1
TIGRFAM:TIGR01073:ATP-dependent DNA helicase PcrA; COG:COG0210: Superfamily I DNA and RNA helicases [DNA replication recombination and repair]; Pfam:PF13361:DNA helicase, UvrD-like, C-terminal; ProSiteProfiles:PS51217:DNA helicase, UvrD-like, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
  
0.934
AHY47829.1
UvrD/REP helicase N-terminal domain; COG:COG0210: Superfamily I DNA and RNA helicases [DNA replication recombination and repair]; Pfam:PF00580:UvrD-like Helicase, ATP-binding domain; ProSiteProfiles:PS51217:DNA helicase, UvrD-like, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the helicase family. UvrD subfamily.
 
 
  
0.859
uvrB
Uvrb: excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits disso [...]
 
 
 0.745
AHY45537.1
TIGRFAM:TIGR00573:DNA polymerase III, epsilon subunit; COG:COG0322: Nuclease subunit of the excinuclease complex [DNA replication recombination and repair]; Pfam:PF00929:Exonuclease, RNase T/DNA polymerase III; ProSiteProfiles:PS50151:UVR domain; SMART:SM00479:Exonuclease; SUPERFAMILY:SSF53098:Ribonuclease H-like domain;KEGG: 00230; KEGG: 00240.
 
  
 0.722
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 
 0.696
AHY45285.1
Dnan: DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiat [...]
 
 
 0.674
AHY46467.1
TIGRFAM:TIGR00614:DNA helicase, ATP-dependent, RecQ type; COG:COG0514: Superfamily II DNA helicase [DNA replication recombination and repair]; Pfam:PF00570:HRDC domain; ProSitePatterns:PS00690:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; ProSiteProfiles:PS51194:Helicase, C-terminal; SMART:SM00487:Helicase, superfamily 1/2, ATP-binding domain; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; recQ_fam.
  
 
 0.662
AHY47830.1
COG:COG2378: Predicted transcriptional regulator [Transcription]; Pfam:PF13280:WYL domain; Pfam:PF13280:WYL domain; PIRSF:PIRSF016838:No Description.
       0.636
AHY47831.1
COG:COG2378: Predicted transcriptional regulator [Transcription]; Pfam:PF13280:WYL domain; Pfam:PF13280:WYL domain; PIRSF:PIRSF016838:No Description.
       0.636
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
   
 
 0.611
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (18%) [HD]
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