STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY47849.1COG:COG2021: Homoserine acetyltransferase [Amino acid transport and metabolism]; Pfam:PF12697:Alpha/beta hydrolase family; Pfam:PF12697:Alpha/beta hydrolase family; PIRSF:PIRSF000443:Homoserine acetyltransferase; SUPERFAMILY:SSF53474:No Description; Belongs to the AB hydrolase superfamily. MetX family. (356 aa)    
Predicted Functional Partners:
AHY46330.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; TIGRFAM:TIGR01326:O-acetylhomoserine/O-acetylserine sulfhydrylase; COG:COG2873: O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Pfam:PF01053:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PIRSF:PIRSF001434:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; ProSitePatterns:PS00868:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase;KEGG: 00270; MetaCyc: PWY-5344; OAH_OAS_sulfhy.
 
 
 0.968
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
  
  
 
0.927
AHY46332.1
COG:COG0460: Homoserine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00742:Homoserine dehydrogenase, catalytic; Pfam:PF00742:Homoserine dehydrogenase, catalytic; PIRSF:PIRSF036497:Homoserine dehydrogenase, short; SUPERFAMILY:SSF55347:No Description.
 
 
 0.917
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.821
trpB-2
trpB: tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.803
AHY45436.1
pssA: CDP-diacylglycerol-serine O-phosphatidyltransferase; TIGRFAM:TIGR00473:CDP-diacylglycerol--serine O-phosphatidyltransferase; COG:COG1183: Phosphatidylserine synthase [Lipid metabolism]; Pfam:PF01066:CDP-alcohol phosphatidyltransferase; ProSitePatterns:PS00379:CDP-alcohol phosphatidyltransferase;KEGG: 00260; KEGG: 00564; MetaCyc: PWY-5669; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.800
trpB
Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.800
trpA
trpA: tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.800
AHY46012.1
metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.655
AHY46129.1
Methyltransferase domain; COG:COG2226: Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Pfam:PF08241:Methyltransferase type 11; SUPERFAMILY:SSF53335:No Description.
  
  
 0.625
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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