STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AHY47899.1COG:COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; ProSitePatterns:PS00187:TPP-binding enzyme, conserved site; SUPERFAMILY:SSF52518:No Description. (589 aa)    
Predicted Functional Partners:
ilvC
ilvC: ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.981
leuB
leuB: 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.947
AHY45504.1
TIGRFAM:TIGR00118:Acetolactate synthase, large subunit, biosynthetic; COG:COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; ProSitePatterns:PS00187:TPP-binding enzyme, conserved site; SUPERFAMILY:SSF52518:No Description;KEGG: 00290; KEGG: 00650; KEGG: 00660; KEGG: 00770; MetaCyc: PWY-5103; MetaCyc: PWY-5939; UniPathway: UPA00047; UniPathwa [...]
  
  
 
0.928
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.905
AHY47895.1
COG:COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Pfam:PF02776:Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; SUPERFAMILY:SSF52518:No Description.
  
  
 
0.904
AHY46083.1
TIGRFAM:TIGR01064:Pyruvate kinase; COG:COG0469: Pyruvate kinase [Carbohydrate transport and metabolism]; Pfam:PF00224:Pyruvate kinase, barrel; PRINTS:PR01050:Pyruvate kinase; ProSitePatterns:PS00110:Pyruvate kinase, active site; SUPERFAMILY:SSF51621:Pyruvate/Phosphoenolpyruvate kinase-like domain;KEGG: 00010; KEGG: 00230; KEGG: 00620; KEGG: 00710; MetaCyc: PWY-2221; Reactome: REACT_474; UniPathway: UPA00109; pyruv_kin.
  
 0.874
AHY45495.1
TIGRFAM:TIGR00977:2-isopropylmalate synthase/homocitrate synthase-related; COG:COG0119: Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Pfam:PF00682:Pyruvate carboxyltransferase; ProSitePatterns:PS00815:Alpha-isopropylmalate/homocitrate synthase, conserved site; ProSiteProfiles:PS50991:Pyruvate carboxyltransferase; SMART:SM00917:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SUPERFAMILY:SSF51569:No Description;KEGG: 00966; LeuA_rel; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.868
AHY47920.1
TIGRFAM:TIGR03966:Heme/flavin dehydrogenase, Rv0694; COG:COG1304: L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases [Energy production and conversion]; Pfam:PF01070:FMN-dependent dehydrogenase; PIRSF:PIRSF000138:Alpha-hydroxy acid dehydrogenase, FMN-dependent; ProSiteProfiles:PS51349:Alpha-hydroxy acid dehydrogenase, FMN-dependent; SUPERFAMILY:SSF51395:No Description; actino_HemFlav.
  
 
 0.842
AHY47773.1
FAD binding domain; COG:COG0277: FAD/FMN-containing dehydrogenases [Energy production and conversion]; Pfam:PF01565:FAD linked oxidase, N-terminal; ProSiteProfiles:PS51387:FAD-binding, type 2; SUPERFAMILY:SSF56176:FAD-binding, type 2;MetaCyc: PWY-6386; UniPathway: UPA00219.
   
 0.839
AHY46003.1
Dehydratase family; COG:COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Pfam:PF00920:Dihydroxy-acid/6-phosphogluconate dehydratase; SUPERFAMILY:SSF52016:Aconitase/3-isopropylmalate dehydratase, swivel;MetaCyc: PWY-5103; UniPathway: UPA00047; UniPathway: UPA00049; Belongs to the IlvD/Edd family.
 
  
 0.836
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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