STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AHY47977.1ATPcob(I)alamin adenosyltransferase; TIGRFAM:TIGR00636:Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like; COG:COG2096: Uncharacterized conserved protein [Function unknown]; Pfam:PF01923:Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like; SUPERFAMILY:SSF89028:Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like;KEGG: 00860; MetaCyc: PWY-5508; MetaCyc: PWY-6268; MetaCyc: PWY-6269; PduO_Nterm. (174 aa)    
Predicted Functional Partners:
AHY47174.1
COG:COG3193: Uncharacterized protein possibly involved in utilization of glycolate and propanediol [General function prediction only]; Pfam:PF03928:Domain of unknown function DUF336; Pfam:PF03928:Domain of unknown function DUF336; SUPERFAMILY:SSF143744:No Description.
     0.927
AHY46098.1
cobA: cob(I)yrinic acid a,c-diamide adenosyltransferase; TIGRFAM:TIGR00708:Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR; COG:COG2109: ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Pfam:PF02572:Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR; PIRSF:PIRSF015617:Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase;KEGG: 00860; MetaCyc: PWY-5508; MetaCyc: PWY-6268; MetaCyc: PWY-6269; UniPathway: UPA00148.
    
 0.926
cobS
cobS: cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
    
 0.923
AHY46095.1
TIGRFAM:TIGR02257:Cobaltochelatase, CobN subunit; COG:COG1429: Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Pfam:PF02514:CobN/magnesium chelatase;KEGG: 00860; UniPathway: UPA00148; cobalto_cobN.
    
 0.919
AHY46113.1
COG:COG2087: Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]; Pfam:PF02283:Cobinamide kinase/cobinamide phosphate guanyltransferase; Pfam:PF02283:Cobinamide kinase/cobinamide phosphate guanyltransferase; PIRSF:PIRSF006135:Cobinamide kinase/cobinamide phosphate guanyltransferase; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
    
 0.919
cobQ
cobQ: cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 
 0.916
cobB
cobB: cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
    
 0.915
cobD
cobD: cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
    
 0.915
AHY46103.1
CbiE: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; TIGRFAM:TIGR02467:Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; COG:COG2242: Precorrin-6B methylase 2 [Coenzyme metabolism]; Pfam:PF00590:Tetrapyrrole methylase; PIRSF:PIRSF036428:Cobalamin (vitamin B12) biosynthesis CobL, precorrin-6Y C5,15-methyltransferase; SUPERFAMILY:SSF53790:Tetrapyrrole methylase.
     
 0.637
AHY47978.1
Putative F420-dependent oxidoreductase, Rv1855c family; TIGRFAM:TIGR03560:F420-dependent oxidoreductase-predicted, Rv1855c; COG:COG2141: Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Pfam:PF00296:Luciferase-like domain; SUPERFAMILY:SSF51679:Luciferase-like domain.
       0.623
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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