STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
gcvHgcvH: glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)    
Predicted Functional Partners:
gcvT
gcvT: glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
AHY48025.1
COG:COG1003: Glycine cleavage system protein P (pyridoxal-binding) C-terminal domain [Amino acid transport and metabolism]; Pfam:PF02347:Glycine cleavage system P-protein, N-terminal; Pfam:PF02347:Glycine cleavage system P-protein, N-terminal; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
 0.999
gcvPA
Glycine cleavage system protein P (pyridoxal-binding) N-terminal domain; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 0.999
AHY45915.1
COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; PIRSF:PIRSF006487:Glycine cleavage system T protein; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
 0.997
AHY45678.1
TIGRFAM:TIGR01350:Dihydrolipoamide dehydrogenase; COG:COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes [Energy production and conversion]; Pfam:PF07992:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; PRINTS:PR00411:Pyridine nucleotide disulphide reductase class-I signature; ProSitePatterns:PS00076:Pyridine nucleotide-disulphide oxidoreductase, class I, active site; SUPERFAMILY:SSF51905:No Description;KEGG: 00010; KEGG: 00020; KEGG: 00260; KEGG: 00280; KEGG: 00620; MetaCyc: PWY-5046; MetaCy [...]
 
  
 0.981
AHY45912.1
COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; PIRSF:PIRSF006487:Glycine cleavage system T protein; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
 
 0.972
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.969
AHY45911.1
FAD dependent oxidoreductase; COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01266:FAD dependent oxidoreductase; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
 
 0.920
lipB
lipB: lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
   
 0.916
AHY47837.1
COG:COG0069: Glutamate synthase domain 2 [Amino acid transport and metabolism]; Pfam:PF01645:Glutamate synthase, central-C; ProSiteProfiles:PS51278:Glutamine amidotransferase type 2 domain; SUPERFAMILY:SSF51395:No Description;UniPathway: UPA00045.
   
 
 0.901
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (18%) [HD]
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