MNS3 protein (Helianthus annuus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

MNS3

alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (619 aa)

Predicted Functional Partners:

MNS2

0.953

MNS1

0.953

RSW3

0.942

GCS1

0.691

ALG12

0.648

A0A251SI18

0.560

EBS1

0.539

A0A251TBI8

0.510

OST3

0.508

ALG3

0.501

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251SI18	ALG12	A0A251SI18	A0A251RT18	Mannosyltransferase.	Mannosyltransferase.	0.998
A0A251SI18	ALG3	A0A251SI18	A0A251T629	Mannosyltransferase.	Putative asparagine-linked glycosylation 3.	0.998
A0A251SI18	EBS1	A0A251SI18	A0A251TTF1	Mannosyltransferase.	Putative UDP-glucose:glycoprotein glucosyltransferase.	0.536
A0A251SI18	MNS1	A0A251SI18	A0A251TNA4	Mannosyltransferase.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.546
A0A251SI18	MNS2	A0A251SI18	A0A251T2X7	Mannosyltransferase.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.546
A0A251SI18	MNS3	A0A251SI18	A0A251S8Y7	Mannosyltransferase.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.560
A0A251TBI8	ALG12	A0A251TBI8	A0A251RT18	Putative beta-1,2-N-acetylglucosaminyltransferase II.	Mannosyltransferase.	0.497
A0A251TBI8	ALG3	A0A251TBI8	A0A251T629	Putative beta-1,2-N-acetylglucosaminyltransferase II.	Putative asparagine-linked glycosylation 3.	0.530
A0A251TBI8	GCS1	A0A251TBI8	A0A251RLY0	Putative beta-1,2-N-acetylglucosaminyltransferase II.	Putative glucosidase 1.	0.564
A0A251TBI8	MNS1	A0A251TBI8	A0A251TNA4	Putative beta-1,2-N-acetylglucosaminyltransferase II.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.536
A0A251TBI8	MNS2	A0A251TBI8	A0A251T2X7	Putative beta-1,2-N-acetylglucosaminyltransferase II.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.536
A0A251TBI8	MNS3	A0A251TBI8	A0A251S8Y7	Putative beta-1,2-N-acetylglucosaminyltransferase II.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.510
ALG12	A0A251SI18	A0A251RT18	A0A251SI18	Mannosyltransferase.	Mannosyltransferase.	0.998
ALG12	A0A251TBI8	A0A251RT18	A0A251TBI8	Mannosyltransferase.	Putative beta-1,2-N-acetylglucosaminyltransferase II.	0.497
ALG12	ALG3	A0A251RT18	A0A251T629	Mannosyltransferase.	Putative asparagine-linked glycosylation 3.	0.959
ALG12	EBS1	A0A251RT18	A0A251TTF1	Mannosyltransferase.	Putative UDP-glucose:glycoprotein glucosyltransferase.	0.587
ALG12	GCS1	A0A251RT18	A0A251RLY0	Mannosyltransferase.	Putative glucosidase 1.	0.552
ALG12	MNS1	A0A251RT18	A0A251TNA4	Mannosyltransferase.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.585
ALG12	MNS2	A0A251RT18	A0A251T2X7	Mannosyltransferase.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.589
ALG12	MNS3	A0A251RT18	A0A251S8Y7	Mannosyltransferase.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.648

page 1 of 5

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010693

Negative regulation of alkaline phosphatase activity

6 of 9

3.45

8.14

1.45e-15

GO:0043931

Ossification involved in bone maturation

6 of 12

3.32

7.95

2.69e-15

GO:0048843

Negative regulation of axon extension involved in axon guidance

7 of 78

2.58

6.82

2.19e-14

GO:0071526

Semaphorin-plexin signaling pathway

8 of 167

2.31

6.37

9.89e-15

GO:0001755

Neural crest cell migration

7 of 184

2.21

5.22

2.82e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030215

Semaphorin receptor binding

7 of 76

2.59

6.69

4.55e-14

GO:0045499

Chemorepellent activity

7 of 97

2.48

6.34

1.16e-13

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005887

Integral component of plasma membrane

8 of 2789

1.08

1.13

3.16e-05

GO:0005615

Extracellular space

7 of 2286

1.11

1.12

8.61e-05

GO:0005886

Plasma membrane

10 of 11711

0.56

0.43

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:62160

Plexin repeat, and Semaphorin receptor complex

6 of 34

2.87

6.81

1.29e-13

CL:62158

Semaphorin-plexin signaling pathway

7 of 100

2.47

6.33

1.06e-13

CL:62145

Semaphorin-plexin signaling pathway

8 of 161

2.32

6.19

3.88e-14

CL:62161

Plexin repeat, and Semaphorin receptor complex

5 of 28

2.88

5.61

3.08e-11

CL:62163

Plexin repeat, and Semaphorin receptor complex

4 of 22

2.89

4.27

1.22e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-416700

Other semaphorin interactions

7 of 48

2.79

7.71

1.21e-15

MAP-416550

Sema4D mediated inhibition of cell attachment and migration

6 of 22

3.06

7.5

1.05e-14

MAP-416572

Sema4D induced cell migration and growth-cone collapse

6 of 38

2.82

6.77

1.24e-13

MAP-400685

Sema4D in semaphorin signaling

6 of 49

2.71

6.46

3.21e-13

MAP-373755

Semaphorin interactions

8 of 267

2.1

5.4

1.24e-13

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 27372

0.23

0.22

0.0268

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0393

Immunoglobulin domain

3 of 178

1.85

1.24

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001627

Sema domain

7 of 88

2.53

6.18

3.90e-13

IPR036352

Sema domain superfamily

7 of 92

2.51

6.15

3.90e-13

IPR027231

Semaphorin

6 of 64

2.6

5.55

1.43e-11

IPR002165

Plexin repeat

4 of 41

2.61

3.35

5.03e-07

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

7 of 594

1.7

2.76

4.61e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00630

Semaphorin domain

6 of 63

2.6

5.86

3.34e-12

SM00423

Domain found in Plexins, Semaphorins and Integrins

4 of 73

2.36

3.09

9.66e-07

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 46

2.26

0.97

0.0161

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