A0A251TPH1 protein (Helianthus annuus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A251TPH1

Putative serine/threonine-protein kinase pim-1/2/3; Belongs to the protein kinase superfamily. (446 aa)

Predicted Functional Partners:

A0A251TYN1

0.811

A0A251SY24

0.703

A0A251SW93

0.608

A0A251SEB6

0.584

A0A251ULD5

0.584

A0A251S4K5

0.577

A0A251S6A8

0.577

A0A251SLJ7

0.577

A0A251U7K7

0.532

A0A251VFX3

0.476

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A251S4K5	A0A251S6A8	RIO domain-containing protein.	RIO domain-containing protein.	0.543
A0A251S4K5	A0A251SEB6	RIO domain-containing protein.	Bms1-type G domain-containing protein.	0.991
A0A251S4K5	A0A251SLJ7	RIO domain-containing protein.	RIO domain-containing protein.	0.543
A0A251S4K5	A0A251SW93	RIO domain-containing protein.	Uncharacterized protein; Belongs to the NOB1 family.	0.995
A0A251S4K5	A0A251SY24	RIO domain-containing protein.	Putative bystin.	0.994
A0A251S4K5	A0A251TPH1	RIO domain-containing protein.	Putative serine/threonine-protein kinase pim-1/2/3; Belongs to the protein kinase superfamily.	0.577
A0A251S4K5	A0A251TYN1	RIO domain-containing protein.	Uncharacterized protein.	0.997
A0A251S4K5	A0A251U7K7	RIO domain-containing protein.	Putative RNA-binding KH domain-containing protein.	0.988
A0A251S4K5	A0A251ULD5	RIO domain-containing protein.	Putative ribosome biogenesis protein BMS1/TSR1, AARP2CN.	0.991
A0A251S6A8	A0A251S4K5	RIO domain-containing protein.	RIO domain-containing protein.	0.543
A0A251S6A8	A0A251SEB6	RIO domain-containing protein.	Bms1-type G domain-containing protein.	0.991
A0A251S6A8	A0A251SLJ7	RIO domain-containing protein.	RIO domain-containing protein.	0.900
A0A251S6A8	A0A251SW93	RIO domain-containing protein.	Uncharacterized protein; Belongs to the NOB1 family.	0.995
A0A251S6A8	A0A251SY24	RIO domain-containing protein.	Putative bystin.	0.994
A0A251S6A8	A0A251TPH1	RIO domain-containing protein.	Putative serine/threonine-protein kinase pim-1/2/3; Belongs to the protein kinase superfamily.	0.577
A0A251S6A8	A0A251TYN1	RIO domain-containing protein.	Uncharacterized protein.	0.997
A0A251S6A8	A0A251U7K7	RIO domain-containing protein.	Putative RNA-binding KH domain-containing protein.	0.988
A0A251S6A8	A0A251ULD5	RIO domain-containing protein.	Putative ribosome biogenesis protein BMS1/TSR1, AARP2CN.	0.991
A0A251SEB6	A0A251S4K5	Bms1-type G domain-containing protein.	RIO domain-containing protein.	0.991
A0A251SEB6	A0A251S6A8	Bms1-type G domain-containing protein.	RIO domain-containing protein.	0.991

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.738

expected number of edges:

12

PPI enrichment p-value:

1.48e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097105

Presynaptic membrane assembly

6 of 7

3.07

6.77

2.79e-13

GO:0097104

Postsynaptic membrane assembly

6 of 7

3.07

6.77

2.79e-13

GO:0048488

Synaptic vesicle endocytosis

6 of 31

2.42

5.17

3.41e-11

GO:0007528

Neuromuscular junction development

6 of 72

2.05

3.83

2.73e-09

GO:0046865

Terpenoid transport

3 of 6

2.83

2.91

4.54e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042043

Neurexin family protein binding

6 of 10

2.91

6.57

4.35e-13

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097060

Synaptic membrane

6 of 96

1.93

3.21

4.00e-08

GO:0098820

Trans-synaptic protein complex

3 of 3

3.13

3.04

3.04e-06

GO:0099056

Integral component of presynaptic membrane

3 of 4

3.01

2.99

3.55e-06

GO:0043195

Terminal bouton

3 of 58

1.85

1.51

0.00082

GO:0009986

Cell surface

3 of 61

1.83

1.48

0.00088

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1273

Presynaptic membrane assembly, and FERM adjacent (FA)

7 of 11

2.94

7.98

7.48e-16

CL:1275

Presynaptic membrane assembly

4 of 5

3.04

4.45

6.76e-09

CL:8063

Small-subunit processome, and Endonucleolytic cleavage involved in rRNA processing

3 of 25

2.21

1.84

0.00029

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00983

Drug metabolism - other enzymes

3 of 71

1.76

1.24

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6794361

Neurexins and neuroligins

6 of 26

2.5

5.25

3.62e-11

MAP-6794362

Protein-protein interactions at synapses

6 of 49

2.22

4.36

5.75e-10

MAP-192456

Digestion of dietary lipid

3 of 26

2.2

1.79

0.00036

MAP-8935690

Digestion

3 of 38

2.03

1.57

0.00084

MAP-112316

Neuronal System

6 of 367

1.35

1.48

4.33e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097060

Synaptic membrane

6 of 61

2.13

3.9

3.76e-09

GOCC:0098794

Postsynapse

6 of 70

2.07

3.79

4.11e-09

GOCC:0099056

Integral component of presynaptic membrane

3 of 3

3.13

3.09

2.50e-06

GOCC:0098820

Trans-synaptic protein complex

3 of 3

3.13

3.09

2.50e-06

GOCC:0097464

Thorny excrescence

3 of 3

3.13

3.09

2.50e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00135

Carboxylesterase family

4 of 16

2.53

3.17

9.98e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002018

Carboxylesterase, type B

4 of 21

2.41

2.67

7.92e-06

IPR001791

Laminin G domain

3 of 20

2.31

1.6

0.0010

IPR029058

Alpha/Beta hydrolase fold

4 of 131

1.62

1.19

0.0027

IPR013320

Concanavalin A-like lectin/glucanase domain superfamily

3 of 75

1.74

0.84

0.0218

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00282

Laminin G domain

3 of 18

2.36

1.93

0.00023

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