A0A251TUA3 protein (Helianthus annuus) - STRING interaction network

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Predicted Interactions

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A0A251TUA3

Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (455 aa)

Predicted Functional Partners:

A0A251RKY3

0.995

A0A251RL12

0.954

A0A251S5Q6

0.951

A0A251S5R7

0.951

A0A251S692

0.951

A0A251S9Z6

0.951

A0A1Y3BUG9

0.906

A0A1Y3BUK1

0.906

RSY3

0.906

A0A251SDV7

0.879

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1Y3BUG9	A0A251SDV7	A0A1Y3BUG9	A0A251SDV7	Uncharacterized protein.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.546
A0A1Y3BUG9	A0A251TUA3	A0A1Y3BUG9	A0A251TUA3	Uncharacterized protein.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.906
A0A1Y3BUK1	A0A251SDV7	A0A1Y3BUK1	A0A251SDV7	Uncharacterized protein.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.546
A0A1Y3BUK1	A0A251TUA3	A0A1Y3BUK1	A0A251TUA3	Uncharacterized protein.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.906
A0A251RKY3	A0A251RL12	A0A251RKY3	A0A251RL12	Putative 2-thiocytidine tRNA biosynthesis protein, TtcA.	Putative cytoplasmic tRNA 2-thiolation protein 1.	0.746
A0A251RKY3	A0A251SDV7	A0A251RKY3	A0A251SDV7	Putative 2-thiocytidine tRNA biosynthesis protein, TtcA.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.627
A0A251RKY3	A0A251TUA3	A0A251RKY3	A0A251TUA3	Putative 2-thiocytidine tRNA biosynthesis protein, TtcA.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.995
A0A251RL12	A0A251RKY3	A0A251RL12	A0A251RKY3	Putative cytoplasmic tRNA 2-thiolation protein 1.	Putative 2-thiocytidine tRNA biosynthesis protein, TtcA.	0.746
A0A251RL12	A0A251SDV7	A0A251RL12	A0A251SDV7	Putative cytoplasmic tRNA 2-thiolation protein 1.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.627
A0A251RL12	A0A251TUA3	A0A251RL12	A0A251TUA3	Putative cytoplasmic tRNA 2-thiolation protein 1.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.954
A0A251S5Q6	A0A251SDV7	A0A251S5Q6	A0A251SDV7	Putative pyridoxal phosphate-dependent transferase.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.627
A0A251S5Q6	A0A251TUA3	A0A251S5Q6	A0A251TUA3	Putative pyridoxal phosphate-dependent transferase.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.951
A0A251S5R7	A0A251SDV7	A0A251S5R7	A0A251SDV7	Putative pyridoxal phosphate-dependent transferase.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.627
A0A251S5R7	A0A251TUA3	A0A251S5R7	A0A251TUA3	Putative pyridoxal phosphate-dependent transferase.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.951
A0A251S692	A0A251SDV7	A0A251S692	A0A251SDV7	Putative pyridoxal phosphate-dependent transferase.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.627
A0A251S692	A0A251TUA3	A0A251S692	A0A251TUA3	Putative pyridoxal phosphate-dependent transferase.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.951
A0A251S9Z6	A0A251SDV7	A0A251S9Z6	A0A251SDV7	Putative pyridoxal phosphate-dependent transferase.	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	0.627
A0A251S9Z6	A0A251TUA3	A0A251S9Z6	A0A251TUA3	Putative pyridoxal phosphate-dependent transferase.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	0.951
A0A251SDV7	A0A1Y3BUG9	A0A251SDV7	A0A1Y3BUG9	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	Uncharacterized protein.	0.546
A0A251SDV7	A0A1Y3BUK1	A0A251SDV7	A0A1Y3BUK1	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.	Uncharacterized protein.	0.546

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

21

PPI enrichment p-value:

2.54e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009847

Spore germination

7 of 32

2.01

4.05

3.58e-10

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5204

Spore germination GerAC-like, and Spore germination GerAB

5 of 6

2.59

4.23

7.97e-09

CL:5071

Spore germination, and Sporulation

6 of 78

1.56

2.12

1.54e-06

CL:5068

Cell differentiation, and Protein of unknown function DUF1256

7 of 134

1.39

1.85

1.13e-06

CL:4657

Mixed, incl. YugN-like family, and Positive regulation of sporulation

2 of 5

2.27

1.1

0.0089

CL:4631

Mostly uncharacterized, incl. Cytochrome complex assembly, and Cellular ketone metabolic process

3 of 41

1.53

0.96

0.0089

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03845

Spore germination protein

3 of 9

2.19

1.54

0.0012

PF03323

Bacillus/Clostridium GerA spore germination protein

3 of 10

2.15

1.53

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004995

Bacillus/Clostridium Ger spore germination protein

3 of 9

2.19

1.32

0.0032

IPR004761

Spore germination GerAB

3 of 9

2.19

1.32

0.0032

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