A0A251U1U8 protein (Helianthus annuus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

A0A251U1U8

Putative winged helix-turn-helix DNA-binding domain-containing protein. (105 aa)

Predicted Functional Partners:

ORC1B

0.994

MCM31

0.990

MCM4

0.982

MCM4-2

0.982

MCM8

0.981

MCM6

0.981

ORC2

0.976

ATCDT1B

0.975

ATCDT1A

0.975

A0A251TSA8

0.975

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251TSA8	A0A251U1U8	A0A251TSA8	A0A251U1U8	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	Putative winged helix-turn-helix DNA-binding domain-containing protein.	0.975
A0A251TSA8	MCM31	A0A251TSA8	A0A251V1V5	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	DNA helicase.	0.995
A0A251TSA8	MCM4	A0A251TSA8	A0A251SR59	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A251TSA8	MCM4-2	A0A251TSA8	A0A251V355	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A251TSA8	MCM6	A0A251TSA8	A0A251UA83	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A251TSA8	MCM8	A0A251TSA8	A0A251SR73	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	Putative DNA helicase MCM8; Belongs to the MCM family.	0.992
A0A251TSA8	ORC1B	A0A251TSA8	A0A251UBW5	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.995
A0A251TSA8	ORC2	A0A251TSA8	A0A251UWP1	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	Putative origin of replication complex subunit 2.	0.989
A0A251U1U8	A0A251TSA8	A0A251U1U8	A0A251TSA8	Putative winged helix-turn-helix DNA-binding domain-containing protein.	Putative winged helix-turn-helix DNA-binding domain, CDT1 Geminin-binding domain-like protein.	0.975
A0A251U1U8	ATCDT1A	A0A251U1U8	A0A251TG58	Putative winged helix-turn-helix DNA-binding domain-containing protein.	Putative CDT1-A-like protein.	0.975
A0A251U1U8	ATCDT1B	A0A251U1U8	A0A251S5C7	Putative winged helix-turn-helix DNA-binding domain-containing protein.	Putative CDT1-B-like protein.	0.975
A0A251U1U8	MCM31	A0A251U1U8	A0A251V1V5	Putative winged helix-turn-helix DNA-binding domain-containing protein.	DNA helicase.	0.990
A0A251U1U8	MCM4	A0A251U1U8	A0A251SR59	Putative winged helix-turn-helix DNA-binding domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.982
A0A251U1U8	MCM4-2	A0A251U1U8	A0A251V355	Putative winged helix-turn-helix DNA-binding domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.982
A0A251U1U8	MCM6	A0A251U1U8	A0A251UA83	Putative winged helix-turn-helix DNA-binding domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.981
A0A251U1U8	MCM8	A0A251U1U8	A0A251SR73	Putative winged helix-turn-helix DNA-binding domain-containing protein.	Putative DNA helicase MCM8; Belongs to the MCM family.	0.981
A0A251U1U8	ORC1B	A0A251U1U8	A0A251UBW5	Putative winged helix-turn-helix DNA-binding domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.994
A0A251U1U8	ORC2	A0A251U1U8	A0A251UWP1	Putative winged helix-turn-helix DNA-binding domain-containing protein.	Putative origin of replication complex subunit 2.	0.976
ATCDT1A	A0A251U1U8	A0A251TG58	A0A251U1U8	Putative CDT1-A-like protein.	Putative winged helix-turn-helix DNA-binding domain-containing protein.	0.975
ATCDT1A	MCM31	A0A251TG58	A0A251V1V5	Putative CDT1-A-like protein.	DNA helicase.	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.849

expected number of edges:

46

PPI enrichment p-value:

0.999

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006635

Fatty acid beta-oxidation

7 of 45

2.32

5.45

2.75e-12

GO:0009062

Fatty acid catabolic process

8 of 69

2.19

5.42

5.90e-13

GO:0046395

Carboxylic acid catabolic process

9 of 173

1.84

4.27

9.38e-13

GO:0033540

Fatty acid beta-oxidation using acyl-CoA oxidase

3 of 5

2.9

2.81

7.18e-06

GO:0032787

Monocarboxylic acid metabolic process

9 of 364

1.52

2.77

1.50e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003997

acyl-CoA oxidase activity

3 of 6

2.82

2.28

6.92e-05

GO:0003988

acetyl-CoA C-acyltransferase activity

3 of 7

2.76

2.27

6.92e-05

GO:0050633

acetyl-CoA C-myristoyltransferase activity

2 of 4

2.82

1.36

0.0034

GO:0050218

propionate-CoA ligase activity

2 of 4

2.82

1.36

0.0034

GO:0003987

acetate-CoA ligase activity

2 of 5

2.73

1.36

0.0034

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

3 of 106

1.58

0.69

0.0412

GO:0005759

Mitochondrial matrix

4 of 247

1.33

0.68

0.0329

GO:0005739

Mitochondrion

6 of 1111

0.86

0.47

0.0412

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37893980

(2023) The Identification of Functional Genes Affecting Fat-Related Meat Traits in Meat-Type Pigeons Using Double-Digest Restriction-Associated DNA Sequencing and Molecular Docking Analysis.

4 of 16

2.52

3.1

1.31e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7145

Fatty acid degradation, and Valine catabolic process

10 of 23

2.76

11.37

9.07e-24

CL:7142

Fatty acid beta-oxidation, and Branched-chain amino acid catabolic process

11 of 38

2.59

11.21

5.86e-25

CL:7147

Mixed, incl. Beta oxidation of octanoyl-CoA to hexanoyl-CoA, and Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

9 of 17

2.85

10.74

7.45e-22

CL:7168

Beta oxidation of butanoyl-CoA to acetyl-CoA, and Thymine metabolic process

5 of 5

3.12

6.11

5.73e-12

CL:7151

Mixed, incl. Fatty acid beta-oxidation multienzyme complex, and acetyl-CoA hydrolase activity

3 of 6

2.82

2.81

6.73e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

clv00640

Propanoate metabolism

7 of 29

2.51

6.75

1.61e-14

clv00071

Fatty acid degradation

6 of 33

2.38

5.36

9.16e-12

clv00280

Valine, leucine and isoleucine degradation

6 of 41

2.29

5.06

2.01e-11

clv01212

Fatty acid metabolism

6 of 51

2.19

4.73

5.07e-11

clv01200

Carbon metabolism

5 of 98

1.83

2.83

1.95e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77289

Mitochondrial Fatty Acid Beta-Oxidation

5 of 37

2.25

3.57

5.77e-08

MAP-8978868

Fatty acid metabolism

8 of 185

1.76

3.48

2.10e-10

MAP-77350

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

3 of 6

2.82

2.75

8.80e-06

MAP-77348

Beta oxidation of octanoyl-CoA to hexanoyl-CoA

3 of 6

2.82

2.75

8.80e-06

MAP-77310

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

3 of 6

2.82

2.75

8.80e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001630

Right ventricle

3 of 18

2.35

2.8

3.76e-06

BTO:0001489

Whole body

11 of 9568

0.18

0.21

0.0170

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

3 of 93

1.63

0.83

0.0213

GOCC:0005739

Mitochondrion

6 of 701

1.06

0.78

0.0047

GOCC:0005737

Cytoplasm

11 of 4626

0.5

0.38

0.0047

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 77

1.71

1.03

0.0080

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00108

Thiolase, N-terminal domain

3 of 4

3.0

2.58

2.03e-05

PF14749

Acyl-coenzyme A oxidase N-terminal

2 of 3

2.95

1.29

0.0047

PF02803

Thiolase, C-terminal domain

2 of 5

2.73

1.2

0.0066

PF13193

AMP-binding enzyme C-terminal domain

2 of 11

2.38

0.95

0.0183

PF02770

Acyl-CoA dehydrogenase, middle domain

2 of 11

2.38

0.95

0.0183

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020610

Thiolase, active site

3 of 5

2.9

2.2

0.00010

IPR020617

Thiolase, C-terminal

3 of 6

2.82

2.19

0.00010

IPR020616

Thiolase, N-terminal

3 of 6

2.82

2.19

0.00010

IPR020613

Thiolase, conserved site

3 of 6

2.82

2.19

0.00010

IPR002155

Thiolase

3 of 6

2.82

2.19

0.00010

(more ...)

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