STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIP2Putative signal peptide peptidase 2. (337 aa)    
Predicted Functional Partners:
A0A251T5V4
Putative histidine triad (HIT) protein.
   
  
 0.561
PS2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
      
 0.504
PS1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
      
 0.503
A0A251U1L5
Putative microsomal signal peptidase 12kDa subunit.
   
  
 0.486
A0A251S3Y9
Putative zn-dependent exopeptidases superfamily protein.
      
 0.483
ATRBL15
Putative RHOMBOID-like protein 15.
   
  
 0.462
A0A251RLU0
Uncharacterized protein.
      
 0.451
MNS2
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
      
 0.437
MNS1
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
      
 0.437
A0A251S0B7
Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.
   
 
 0.425
Your Current Organism:
Helianthus annuus
NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.