A0A251U5E8 protein (Helianthus annuus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

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[Homology]

Score

A0A251U5E8

Uncharacterized protein. (90 aa)

Predicted Functional Partners:

CYP51G1

0.978

STE1

0.964

A0A251UB33

0.964

ERG28

0.925

A0A251SBW7

0.823

A0A251SIG6

0.823

SQP1

0.823

A0A251TR65

0.823

A0A251ULQ0

0.823

A0A251UN24

0.823

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251SBW7	A0A251U5E8	A0A251SBW7	A0A251U5E8	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Uncharacterized protein.	0.823
A0A251SBW7	A0A251UB33	A0A251SBW7	A0A251UB33	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.700
A0A251SBW7	CYP51G1	A0A251SBW7	A0A251RM88	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative CYTOCHROME P450 51G1; Belongs to the cytochrome P450 family.	0.914
A0A251SBW7	ERG28	A0A251SBW7	A0A251TIP4	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative ergosterol28-like protein.	0.551
A0A251SBW7	STE1	A0A251SBW7	A0A251SGN5	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative sterol 1; Belongs to the sterol desaturase family.	0.700
A0A251SIG6	A0A251U5E8	A0A251SIG6	A0A251U5E8	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Uncharacterized protein.	0.823
A0A251SIG6	A0A251UB33	A0A251SIG6	A0A251UB33	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.700
A0A251SIG6	CYP51G1	A0A251SIG6	A0A251RM88	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative CYTOCHROME P450 51G1; Belongs to the cytochrome P450 family.	0.914
A0A251SIG6	ERG28	A0A251SIG6	A0A251TIP4	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative ergosterol28-like protein.	0.551
A0A251SIG6	STE1	A0A251SIG6	A0A251SGN5	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative sterol 1; Belongs to the sterol desaturase family.	0.700
A0A251TR65	A0A251U5E8	A0A251TR65	A0A251U5E8	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Uncharacterized protein.	0.823
A0A251TR65	A0A251UB33	A0A251TR65	A0A251UB33	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.700
A0A251TR65	CYP51G1	A0A251TR65	A0A251RM88	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative CYTOCHROME P450 51G1; Belongs to the cytochrome P450 family.	0.915
A0A251TR65	ERG28	A0A251TR65	A0A251TIP4	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative ergosterol28-like protein.	0.551
A0A251TR65	STE1	A0A251TR65	A0A251SGN5	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	Putative sterol 1; Belongs to the sterol desaturase family.	0.700
A0A251U5E8	A0A251SBW7	A0A251U5E8	A0A251SBW7	Uncharacterized protein.	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	0.823
A0A251U5E8	A0A251SIG6	A0A251U5E8	A0A251SIG6	Uncharacterized protein.	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	0.823
A0A251U5E8	A0A251TR65	A0A251U5E8	A0A251TR65	Uncharacterized protein.	Putative squalene epoxidase, FAD/NAD(P)-binding domain protein.	0.823
A0A251U5E8	A0A251UB33	A0A251U5E8	A0A251UB33	Uncharacterized protein.	Putative fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.964
A0A251U5E8	A0A251ULQ0	A0A251U5E8	A0A251ULQ0	Uncharacterized protein.	Putative endonuclease/exonuclease/phosphatase.	0.823

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

37

PPI enrichment p-value:

0.00116

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

5 of 50

1.65

2.1

6.14e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

11 of 77

1.8

5.0

2.47e-17

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

11 of 1042

0.67

0.63

5.62e-06

GO:0005886

Plasma membrane

8 of 722

0.69

0.56

0.00084

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4081

Mixed, incl. HPT domain superfamily, and SinI-like, DNA-binding domain

7 of 12

2.42

5.98

4.21e-13

CL:4085

HPT domain superfamily, and Sodium/solute symporter

4 of 5

2.55

3.59

1.49e-07

CL:4062

cheY-homologous receiver domain, and Histidine kinase domain

8 of 75

1.68

3.3

1.11e-10

CL:4058

Phosphorelay signal transduction system, and Nucleotide cyclase

11 of 144

1.53

3.29

2.25e-14

CL:4247

PAC motif

3 of 6

2.35

2.23

5.64e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

10 of 933

0.68

0.59

0.00018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

8 of 94

1.58

2.83

9.40e-10

KW-0418

Kinase

8 of 116

1.49

2.51

2.33e-09

KW-0175

Coiled coil

7 of 374

0.92

0.84

0.00023

KW-0067

ATP-binding

5 of 317

0.85

0.56

0.0138

KW-1133

Transmembrane helix

8 of 1002

0.55

0.38

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 41

1.94

4.29

1.57e-11

IPR035965

PAS domain superfamily

8 of 43

1.92

4.23

1.57e-11

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 44

1.91

4.2

1.57e-11

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

8 of 44

1.91

4.2

1.57e-11

IPR000014

PAS domain

7 of 36

1.94

3.98

1.71e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00091

PAS domain

8 of 42

1.93

4.54

1.43e-12

SM00388

His Kinase A (phosphoacceptor) domain

8 of 49

1.86

4.27

2.19e-12

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

6 of 24

2.05

4.12

3.83e-10

SM00387

Histidine kinase-like ATPases

8 of 58

1.79

3.94

5.05e-12

SM00073

Histidine Phosphotransfer domain

4 of 7

2.41

3.58

1.03e-07

(more ...)

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