node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEN81521.1 | SEO75174.1 | SAMN05216333_101241 | SAMN05216333_11751 | Serine O-acetyltransferase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.920 |
SEN81521.1 | SEO97357.1 | SAMN05216333_101241 | SAMN05216333_13012 | Serine O-acetyltransferase. | Phosphoserine phosphatase. | 0.960 |
SEN81521.1 | glyA | SAMN05216333_101241 | SAMN05216333_101215 | Serine O-acetyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
SEN81521.1 | ilvA | SAMN05216333_101241 | SAMN05216333_1045 | Serine O-acetyltransferase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.916 |
SEN81521.1 | metXS | SAMN05216333_101241 | SAMN05216333_10355 | Serine O-acetyltransferase. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.471 |
SEN81521.1 | trpA | SAMN05216333_101241 | SAMN05216333_11620 | Serine O-acetyltransferase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.916 |
SEN81521.1 | trpB | SAMN05216333_101241 | SAMN05216333_11621 | Serine O-acetyltransferase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.916 |
SEO23016.1 | SEO75174.1 | SAMN05216333_10697 | SAMN05216333_11751 | Alanine-glyoxylate aminotransferase apoenzyme. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.928 |
SEO23016.1 | SEO97357.1 | SAMN05216333_10697 | SAMN05216333_13012 | Alanine-glyoxylate aminotransferase apoenzyme. | Phosphoserine phosphatase. | 0.931 |
SEO23016.1 | glyA | SAMN05216333_10697 | SAMN05216333_101215 | Alanine-glyoxylate aminotransferase apoenzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
SEO23016.1 | ilvA | SAMN05216333_10697 | SAMN05216333_1045 | Alanine-glyoxylate aminotransferase apoenzyme. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.939 |
SEO23016.1 | serC | SAMN05216333_10697 | SAMN05216333_10742 | Alanine-glyoxylate aminotransferase apoenzyme. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.580 |
SEO23016.1 | trpA | SAMN05216333_10697 | SAMN05216333_11620 | Alanine-glyoxylate aminotransferase apoenzyme. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.918 |
SEO23016.1 | trpB | SAMN05216333_10697 | SAMN05216333_11621 | Alanine-glyoxylate aminotransferase apoenzyme. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.922 |
SEO29408.1 | SEO97357.1 | SAMN05216333_107127 | SAMN05216333_13012 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphoserine phosphatase. | 0.918 |
SEO29408.1 | ilvA | SAMN05216333_107127 | SAMN05216333_1045 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.916 |
SEO75174.1 | SEN81521.1 | SAMN05216333_11751 | SAMN05216333_101241 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine O-acetyltransferase. | 0.920 |
SEO75174.1 | SEO23016.1 | SAMN05216333_11751 | SAMN05216333_10697 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Alanine-glyoxylate aminotransferase apoenzyme. | 0.928 |
SEO75174.1 | SEO97357.1 | SAMN05216333_11751 | SAMN05216333_13012 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.924 |
SEO75174.1 | glyA | SAMN05216333_11751 | SAMN05216333_101215 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |