node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ssed_0384 | dut | Ssed_0384 | Ssed_0383 | Phosphopantothenoylcysteine decarboxylase, Phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.969 |
Ssed_0384 | slmA | Ssed_0384 | Ssed_0382 | Phosphopantothenoylcysteine decarboxylase, Phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.585 |
Ssed_1600 | Ssed_2804 | Ssed_1600 | Ssed_2804 | KEGG: slo:Shew_2449 anaerobic ribonucleoside-triphosphate reductase. | KEGG: cps:CPS_0092 anaerobic ribonucleoside triphosphate reductase. | 0.900 |
Ssed_1600 | dut | Ssed_1600 | Ssed_0383 | KEGG: slo:Shew_2449 anaerobic ribonucleoside-triphosphate reductase. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.924 |
Ssed_1600 | ndk | Ssed_1600 | Ssed_2862 | KEGG: slo:Shew_2449 anaerobic ribonucleoside-triphosphate reductase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.911 |
Ssed_2804 | Ssed_1600 | Ssed_2804 | Ssed_1600 | KEGG: cps:CPS_0092 anaerobic ribonucleoside triphosphate reductase. | KEGG: slo:Shew_2449 anaerobic ribonucleoside-triphosphate reductase. | 0.900 |
Ssed_2804 | dut | Ssed_2804 | Ssed_0383 | KEGG: cps:CPS_0092 anaerobic ribonucleoside triphosphate reductase. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.924 |
Ssed_2804 | ndk | Ssed_2804 | Ssed_2862 | KEGG: cps:CPS_0092 anaerobic ribonucleoside triphosphate reductase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.911 |
Ssed_3657 | dut | Ssed_3657 | Ssed_0383 | KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.947 |
Ssed_3657 | surE | Ssed_3657 | Ssed_1295 | KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Ssed_3657 | tdk | Ssed_3657 | Ssed_1449 | KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | KEGG: sdn:Sden_2536 thymidine kinase. | 0.941 |
Ssed_3657 | thyA | Ssed_3657 | Ssed_1135 | KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.948 |
Ssed_3657 | tmk | Ssed_3657 | Ssed_2648 | KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.941 |
dut | Ssed_0384 | Ssed_0383 | Ssed_0384 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Phosphopantothenoylcysteine decarboxylase, Phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.969 |
dut | Ssed_1600 | Ssed_0383 | Ssed_1600 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | KEGG: slo:Shew_2449 anaerobic ribonucleoside-triphosphate reductase. | 0.924 |
dut | Ssed_2804 | Ssed_0383 | Ssed_2804 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | KEGG: cps:CPS_0092 anaerobic ribonucleoside triphosphate reductase. | 0.924 |
dut | Ssed_3657 | Ssed_0383 | Ssed_3657 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | 0.947 |
dut | ndk | Ssed_0383 | Ssed_2862 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.936 |
dut | slmA | Ssed_0383 | Ssed_0382 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.922 |
dut | surE | Ssed_0383 | Ssed_1295 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.914 |