node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ssed_1879 | fhs | Ssed_1879 | Ssed_0612 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.629 |
Ssed_1879 | folD | Ssed_1879 | Ssed_1539 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.905 |
Ssed_1879 | glyA | Ssed_1879 | Ssed_1271 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
Ssed_1879 | guaB | Ssed_1879 | Ssed_3124 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Malate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.936 |
Ssed_1879 | purD | Ssed_1879 | Ssed_0443 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: slo:Shew_3413 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.939 |
Ssed_1879 | purH | Ssed_1879 | Ssed_0444 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase; KEGG: slo:Shew_3412 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.993 |
Ssed_1879 | purL | Ssed_1879 | Ssed_3119 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.996 |
Ssed_1879 | purM | Ssed_1879 | Ssed_1845 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: slo:Shew_1513 phosphoribosylformylglycinamidine cyclo-ligase. | 0.932 |
Ssed_1879 | purN | Ssed_1879 | Ssed_1844 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.935 |
Ssed_1879 | purT | Ssed_1879 | Ssed_0973 | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.424 |
fhs | Ssed_1879 | Ssed_0612 | Ssed_1879 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: slo:Shew_1558 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.629 |
fhs | folD | Ssed_0612 | Ssed_1539 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | glyA | Ssed_0612 | Ssed_1271 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
fhs | guaB | Ssed_0612 | Ssed_3124 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Malate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.449 |
fhs | purD | Ssed_0612 | Ssed_0443 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: slo:Shew_3413 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.700 |
fhs | purH | Ssed_0612 | Ssed_0444 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | IMP cyclohydrolase; KEGG: slo:Shew_3412 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.991 |
fhs | purL | Ssed_0612 | Ssed_3119 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.942 |
fhs | purM | Ssed_0612 | Ssed_1845 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: slo:Shew_1513 phosphoribosylformylglycinamidine cyclo-ligase. | 0.488 |
fhs | purN | Ssed_0612 | Ssed_1844 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.971 |
fhs | purT | Ssed_0612 | Ssed_0973 | KEGG: slo:Shew_0443 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxylase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |