Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
Score
Ssed_1237KEGG: slo:Shew_1144 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (186 aa)    
Predicted Functional Partners:
Ssed_2306
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 0.964
Ssed_1236
Putative Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family.
  
  
 0.949
Ssed_0007
DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...]
  
 
 0.821
Ssed_1238
KEGG: sdn:Sden_2675 translation initiation factor SUI1.
       0.640
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
  
 0.595
tdk
KEGG: sdn:Sden_2536 thymidine kinase.
   
  
 0.586
Ssed_2817
Conserved hypothetical succinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
   
    0.529
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
  
 0.520
Ssed_0464
KEGG: slo:Shew_3387 band 7 protein.
  
    0.520
Ssed_0465
KEGG: slo:Shew_3386 band 7 protein.
  
    0.520
Your Current Organism:
Shewanella sediminis
NCBI taxonomy Id: 425104
Other names: S. sediminis HAW-EB3, Shewanella sediminis HAW-EB3, Shewanella sediminis str. HAW-EB3, Shewanella sediminis strain HAW-EB3
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