node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ssed_0007 | dinB | Ssed_0007 | Ssed_3422 | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.869 |
Ssed_0007 | lexA | Ssed_0007 | Ssed_0200 | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | Repressor lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.418 |
Ssed_0007 | polA | Ssed_0007 | Ssed_0096 | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.990 |
Ssed_0007 | recA | Ssed_0007 | Ssed_1300 | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | Calcium-transporting ATPase; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.898 |
Ssed_0007 | rpoA | Ssed_0007 | Ssed_4294 | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.649 |
Ssed_0007 | xni | Ssed_0007 | Ssed_3311 | DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] | 5'-3' exonuclease; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.915 |
Ssed_1281 | Ssed_2172 | Ssed_1281 | Ssed_2172 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | KEGG: vvu:VV1_0390 SOS-response transcriptional repressor LexA -like protein; Belongs to the peptidase S24 family. | 0.700 |
Ssed_1281 | Ssed_3210 | Ssed_1281 | Ssed_3210 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | KEGG: sfr:Sfri_0228 regulatory protein RecX. | 0.597 |
Ssed_1281 | Ssed_3370 | Ssed_1281 | Ssed_3370 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Methylated-DNA--(protein)-cysteine S-methyltransferase; KEGG: slo:Shew_2807 DNA repair protein RadA. | 0.566 |
Ssed_1281 | dinB | Ssed_1281 | Ssed_3422 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.476 |
Ssed_1281 | lexA | Ssed_1281 | Ssed_0200 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Repressor lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.700 |
Ssed_1281 | polA | Ssed_1281 | Ssed_0096 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.587 |
Ssed_1281 | recA | Ssed_1281 | Ssed_1300 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Calcium-transporting ATPase; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.907 |
Ssed_2172 | Ssed_1281 | Ssed_2172 | Ssed_1281 | KEGG: vvu:VV1_0390 SOS-response transcriptional repressor LexA -like protein; Belongs to the peptidase S24 family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.700 |
Ssed_2172 | dinB | Ssed_2172 | Ssed_3422 | KEGG: vvu:VV1_0390 SOS-response transcriptional repressor LexA -like protein; Belongs to the peptidase S24 family. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.768 |
Ssed_2172 | polA | Ssed_2172 | Ssed_0096 | KEGG: vvu:VV1_0390 SOS-response transcriptional repressor LexA -like protein; Belongs to the peptidase S24 family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.404 |
Ssed_2172 | recA | Ssed_2172 | Ssed_1300 | KEGG: vvu:VV1_0390 SOS-response transcriptional repressor LexA -like protein; Belongs to the peptidase S24 family. | Calcium-transporting ATPase; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.964 |
Ssed_3210 | Ssed_1281 | Ssed_3210 | Ssed_1281 | KEGG: sfr:Sfri_0228 regulatory protein RecX. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.597 |
Ssed_3210 | Ssed_3370 | Ssed_3210 | Ssed_3370 | KEGG: sfr:Sfri_0228 regulatory protein RecX. | Methylated-DNA--(protein)-cysteine S-methyltransferase; KEGG: slo:Shew_2807 DNA repair protein RadA. | 0.912 |
Ssed_3210 | polA | Ssed_3210 | Ssed_0096 | KEGG: sfr:Sfri_0228 regulatory protein RecX. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.490 |