dyrk4 protein (Pygocentrus nattereri) - STRING interaction network

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dyrk4

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4. (620 aa)

Predicted Functional Partners:

tp53

0.697

LOC108436226

0.697

dcaf7

0.694

DCAF7

0.694

atm

0.653

lin52

0.624

pin1

0.623

mdm4

0.612

pin4

0.577

mecp2

0.569

Your Current Organism:

Pygocentrus nattereri

NCBI taxonomy Id: 42514
Other names: P. nattereri, Serrasalmus nattereri, red piranha, red-bellied piranha

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCAF7	dyrk4	ENSPNAP00000024715	ENSPNAP00000003044	DDB1 and CUL4 associated factor 7.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	0.694
LOC108436226	atm	ENSPNAP00000030579	ENSPNAP00000006479	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Non-specific serine/threonine protein kinase.	0.991
LOC108436226	dyrk4	ENSPNAP00000030579	ENSPNAP00000003044	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	0.697
LOC108436226	mdm4	ENSPNAP00000030579	ENSPNAP00000026754	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.994
LOC108436226	pin1	ENSPNAP00000030579	ENSPNAP00000011259	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Peptidyl-prolyl cis-trans isomerase.	0.864
LOC108436226	pin4	ENSPNAP00000030579	ENSPNAP00000035589	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Peptidyl-prolyl cis-trans isomerase.	0.539
LOC108436226	tp53	ENSPNAP00000030579	ENSPNAP00000014501	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.876
atm	LOC108436226	ENSPNAP00000006479	ENSPNAP00000030579	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.991
atm	dyrk4	ENSPNAP00000006479	ENSPNAP00000003044	Non-specific serine/threonine protein kinase.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	0.653
atm	mdm4	ENSPNAP00000006479	ENSPNAP00000026754	Non-specific serine/threonine protein kinase.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.873
atm	tp53	ENSPNAP00000006479	ENSPNAP00000014501	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.991
dcaf7	dyrk4	ENSPNAP00000011190	ENSPNAP00000003044	WD_REPEATS_REGION domain-containing protein.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	0.694
dyrk4	DCAF7	ENSPNAP00000003044	ENSPNAP00000024715	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	DDB1 and CUL4 associated factor 7.	0.694
dyrk4	LOC108436226	ENSPNAP00000003044	ENSPNAP00000030579	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.697
dyrk4	atm	ENSPNAP00000003044	ENSPNAP00000006479	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	Non-specific serine/threonine protein kinase.	0.653
dyrk4	dcaf7	ENSPNAP00000003044	ENSPNAP00000011190	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	WD_REPEATS_REGION domain-containing protein.	0.694
dyrk4	lin52	ENSPNAP00000003044	ENSPNAP00000015839	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	Lin-52 DREAM MuvB core complex component.	0.624
dyrk4	mdm4	ENSPNAP00000003044	ENSPNAP00000026754	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.612
dyrk4	mecp2	ENSPNAP00000003044	ENSPNAP00000018347	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	Methyl CpG binding protein 2.	0.569
dyrk4	pin1	ENSPNAP00000003044	ENSPNAP00000011259	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4.	Peptidyl-prolyl cis-trans isomerase.	0.623