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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topbp1DNA topoisomerase II binding protein 1. (1530 aa)    
Predicted Functional Partners:
tp53bp1
Tumor protein p53 binding protein, 1.
    
 
 0.996
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 
 0.995
wrn
WRN RecQ like helicase.
   
 0.994
brca1
Uncharacterized protein.
   
 0.993
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.990
brip1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.989
bard1
BRCA1 associated RING domain 1.
   
 0.988
rtel1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]
   
 0.983
mcm5
DNA helicase; Belongs to the MCM family.
   
 
 0.981
LOC108430356
RAD9 checkpoint clamp component B.
    
 0.979
Your Current Organism:
Pygocentrus nattereri
NCBI taxonomy Id: 42514
Other names: P. nattereri, Serrasalmus nattereri, red piranha, red-bellied piranha
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