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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSPNAP00000005222Uncharacterized protein. (101 aa)    
Predicted Functional Partners:
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.753
LOC108440489
RAN binding protein 2.
   
 0.680
ENSPNAP00000005259
Uncharacterized protein.
 
      0.678
ENSPNAP00000026238
Uncharacterized protein.
 
      0.675
ENSPNAP00000005224
WD_REPEATS_REGION domain-containing protein.
 
      0.664
zfand4
Zinc finger, AN1-type domain 4.
    
 0.644
ND4
NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
    
 
 0.617
ENSPNAP00000003651
Ubiquitin-like domain-containing protein.
    
 0.608
ube2n
Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.608
LOC108424063
RAB guanine nucleotide exchange factor (GEF) 1, like.
    
 0.603
Your Current Organism:
Pygocentrus nattereri
NCBI taxonomy Id: 42514
Other names: P. nattereri, Serrasalmus nattereri, red piranha, red-bellied piranha
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