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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
igf1rTyrosine-protein kinase receptor. (1394 aa)    
Predicted Functional Partners:
LOC108434672
Insulin receptor substrate 2a.
    
 0.957
irs1
Insulin receptor substrate 1.
    
 0.957
irs2
Insulin receptor substrate 2b.
    
 0.957
LOC108412586
Uncharacterized protein.
    
 0.952
ENSPNAP00000019279
Insulin receptor substrate 4a.
    
 0.952
LOC108442825
Si:ch73-335l21.1.
    
 0.952
ins
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.952
pik3r1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).
    
 0.937
grb10
Growth factor receptor-bound protein 10b.
    
 0.937
LOC108438546
Insulin-like growth factor 2a.
    
 0.936
Your Current Organism:
Pygocentrus nattereri
NCBI taxonomy Id: 42514
Other names: P. nattereri, Serrasalmus nattereri, red piranha, red-bellied piranha
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.