STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (400 aa)    
Predicted Functional Partners:
pol3
DNA polymerase.
   
 0.986
exoA
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
   
 0.979
cdc17
DNA ligase.
   
 0.978
pcn1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.972
DNF11_2136
Mysoin-binding motif of peroxisomes.
   
 0.972
MRE11
Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family.
   
 0.969
DNA2
DNA replication ATP-dependent helicase DNA2.
   
 0.953
POLD2
DNA polymerase delta small subunit.
   
 0.935
rqh1
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.918
RFC2
Replication factor C subunit 2.
   
 0.903
Your Current Organism:
Malassezia restricta
NCBI taxonomy Id: 425264
Other names: M. restricta CBS 7877, Malassezia restricta CBS 7877
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.