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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hybDProtein hydD; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)    
Predicted Functional Partners:
KGI53314.1
Hydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 0.991
cybH
Ni/Fe hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.985
KGI53313.1
Ni/Fe hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.975
KGI53938.1
NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.880
KGI53317.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.874
KGI54631.1
Ni/Fe hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.863
KGI53318.1
Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.686
KGI53319.1
Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.676
KGI53320.1
Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.670
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
    
   0.451
Your Current Organism:
Helicobacter japonicus
NCBI taxonomy Id: 425400
Other names: ATCC TSD-46, H. japonicus, Helicobacter japonicum, Helicobacter sp. MIT 01-6451, LMG 28612, LMG:28612, strain MIT 01-6451
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