node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFH82635.1 | SFH97022.1 | SAMN05216206_0395 | SAMN05216206_0924 | DNA polymerase III, alpha subunit. | DNA polymerase-3 subunit epsilon. | 0.974 |
SFH82635.1 | SFI11501.1 | SAMN05216206_0395 | SAMN05216206_1496 | DNA polymerase III, alpha subunit. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.989 |
SFH82635.1 | SFI32768.1 | SAMN05216206_0395 | SAMN05216206_1892 | DNA polymerase III, alpha subunit. | ATP-dependent DNA helicase RecQ. | 0.540 |
SFH82635.1 | SFI86723.1 | SAMN05216206_0395 | SAMN05216206_3029 | DNA polymerase III, alpha subunit. | DNA polymerase III, delta subunit. | 0.987 |
SFH82635.1 | SFJ05083.1 | SAMN05216206_0395 | SAMN05216206_3390 | DNA polymerase III, alpha subunit. | DNA polymerase-3 subunit epsilon. | 0.758 |
SFH82635.1 | dnaX | SAMN05216206_0395 | SAMN05216206_2495 | DNA polymerase III, alpha subunit. | DNA polymerase III, gamma subunit /DNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.989 |
SFH82635.1 | ligA | SAMN05216206_0395 | SAMN05216206_2219 | DNA polymerase III, alpha subunit. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.782 |
SFH82635.1 | ligB | SAMN05216206_0395 | SAMN05216206_1120 | DNA polymerase III, alpha subunit. | DNA ligase (NAD+); Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | 0.631 |
SFH82635.1 | mutM | SAMN05216206_0395 | SAMN05216206_1203 | DNA polymerase III, alpha subunit. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.423 |
SFH82635.1 | uvrB | SAMN05216206_0395 | SAMN05216206_3757 | DNA polymerase III, alpha subunit. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.427 |
SFH97022.1 | SFH82635.1 | SAMN05216206_0924 | SAMN05216206_0395 | DNA polymerase-3 subunit epsilon. | DNA polymerase III, alpha subunit. | 0.974 |
SFH97022.1 | SFI11501.1 | SAMN05216206_0924 | SAMN05216206_1496 | DNA polymerase-3 subunit epsilon. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.974 |
SFH97022.1 | SFI32768.1 | SAMN05216206_0924 | SAMN05216206_1892 | DNA polymerase-3 subunit epsilon. | ATP-dependent DNA helicase RecQ. | 0.933 |
SFH97022.1 | SFI86723.1 | SAMN05216206_0924 | SAMN05216206_3029 | DNA polymerase-3 subunit epsilon. | DNA polymerase III, delta subunit. | 0.920 |
SFH97022.1 | SFJ05083.1 | SAMN05216206_0924 | SAMN05216206_3390 | DNA polymerase-3 subunit epsilon. | DNA polymerase-3 subunit epsilon. | 0.843 |
SFH97022.1 | dnaX | SAMN05216206_0924 | SAMN05216206_2495 | DNA polymerase-3 subunit epsilon. | DNA polymerase III, gamma subunit /DNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.966 |
SFH97022.1 | ligA | SAMN05216206_0924 | SAMN05216206_2219 | DNA polymerase-3 subunit epsilon. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.829 |
SFH97022.1 | ligB | SAMN05216206_0924 | SAMN05216206_1120 | DNA polymerase-3 subunit epsilon. | DNA ligase (NAD+); Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | 0.846 |
SFH97022.1 | mutM | SAMN05216206_0924 | SAMN05216206_1203 | DNA polymerase-3 subunit epsilon. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.900 |
SFH97022.1 | uvrB | SAMN05216206_0924 | SAMN05216206_3757 | DNA polymerase-3 subunit epsilon. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.989 |