STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
uvrDDNA-dependent helicase II; Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)    
Predicted Functional Partners:
FP66_11830
ATP-dependent DNA helicase RuvA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.942
FP66_05880
ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.908
FP66_12880
DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.894
FP66_02705
DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.883
ruvB
ATP-dependent DNA helicase RuvB; Promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.847
mutL
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.844
FP66_00845
Exodeoxyribonuclease V subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.843
FP66_10570
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.820
FP66_06210
DNA topoisomerase I; Catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.796
FP66_07890
DNA helicase; Unwinds double stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.776
Your Current Organism:
Halomonas salina
NCBI taxonomy Id: 42565
Other names: ATCC 49509, CIP 106092, DSM 5928, Deleya salina, H. salina, JCM 21221, strain F8-11
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.